Frontiers in Oncology (Aug 2022)

Emerging role of non-coding RNAs in glucose metabolic reprogramming and chemoresistance in colorectal cancer

  • Shushan Yan,
  • Shufeng Wang,
  • Xinyi Wang,
  • Wenqing Dai,
  • Jinjin Chu,
  • Min Cheng,
  • Zhiliang Guo,
  • Donghua Xu,
  • Donghua Xu

DOI
https://doi.org/10.3389/fonc.2022.954329
Journal volume & issue
Vol. 12

Abstract

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Metabolic reprogramming plays a critical role in colorectal cancer (CRC). It contributes to CRC by shaping metabolic phenotypes and causing uncontrolled proliferation of CRC cells. Glucose metabolic reprogramming is common in carcinogenesis and cancer progression. Growing evidence has implicated the modifying effects of non-coding RNAs (ncRNAs) in glucose metabolic reprogramming and chemoresistance in CRC. In this review, we have summarized currently published studies investigating the role of ncRNAs in glucose metabolic alterations and chemoresistance in CRC. Elucidating the interplay between ncRNAs and glucose metabolic reprogramming provides insight into exploring novel biomarkers for the diagnosis and prognosis prediction of CRC.

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