Large-scale multi-omics analysis suggests specific roles for intragenic cohesin in transcriptional regulation

Jiankang Wang; Masashige Bando; Katsuhiko Shirahige; Ryuichiro Nakato

doi:10.1038/s41467-022-30792-9

Nature Communications (Jun 2022)

Large-scale multi-omics analysis suggests specific roles for intragenic cohesin in transcriptional regulation

Jiankang Wang,
Masashige Bando,
Katsuhiko Shirahige,
Ryuichiro Nakato

Affiliations

Jiankang Wang: Institute for Quantitative Biosciences, The University of Tokyo
Masashige Bando: Institute for Quantitative Biosciences, The University of Tokyo
Katsuhiko Shirahige: Institute for Quantitative Biosciences, The University of Tokyo
Ryuichiro Nakato: Institute for Quantitative Biosciences, The University of Tokyo

DOI: https://doi.org/10.1038/s41467-022-30792-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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Cohesin complex is essential for transcriptional regulation and chromosome folding. Here the authors provide a large-scale multi-omics analysis suggesting that cohesin bound on gene bodies has a specific role in transcriptional regulation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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