Impact of Soluble HLA-G Levels and Endometrial NK Cells  in Uterine Flushing Samples from Primary and Secondary Unexplained Infertile Women

Roberta Rizzo; Giuseppe Lo Monte; Daria Bortolotti; Angela Graziano; Valentina Gentili; Dario Di Luca; Roberto Marci

doi:10.3390/ijms16035510

International Journal of Molecular Sciences (Mar 2015)

Impact of Soluble HLA-G Levels and Endometrial NK Cells in Uterine Flushing Samples from Primary and Secondary Unexplained Infertile Women

Roberta Rizzo,
Giuseppe Lo Monte,
Daria Bortolotti,
Angela Graziano,
Valentina Gentili,
Dario Di Luca,
Roberto Marci

Affiliations

Roberta Rizzo: Department of Medical Sciences, Section of Microbiology and Genetics, University of Ferrara, 44100 Ferrara, Italy
Giuseppe Lo Monte: Department of Morphology, Surgery and Experimental Medicine, Section of Gynecology and Obstetrics, University of Ferrara, 44100 Ferrara, Italy
Daria Bortolotti: Department of Medical Sciences, Section of Microbiology and Genetics, University of Ferrara, 44100 Ferrara, Italy
Angela Graziano: Department of Morphology, Surgery and Experimental Medicine, Section of Gynecology and Obstetrics, University of Ferrara, 44100 Ferrara, Italy
Valentina Gentili: Department of Medical Sciences, Section of Microbiology and Genetics, University of Ferrara, 44100 Ferrara, Italy
Dario Di Luca: Department of Medical Sciences, Section of Microbiology and Genetics, University of Ferrara, 44100 Ferrara, Italy
Roberto Marci: Department of Morphology, Surgery and Experimental Medicine, Section of Gynecology and Obstetrics, University of Ferrara, 44100 Ferrara, Italy

DOI: https://doi.org/10.3390/ijms16035510
Journal volume & issue: Vol. 16, no. 3
pp. 5510 – 5516

Abstract

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The aim of this research was to determine the levels of human leukocyte antigen G (HLA-G) and endometrial Natural Killer ((e)NK) cell percentages in uterine flushing samples from primary and secondary infertile women. sHLA-G levels were lower in the uterine flushing samples from primary infertile women in comparison with women with secondary infertility. Lower CD56+KIR2DL4+ (e)NK cell percentages were detected in primary infertile women compared with secondary infertile women. This is the first study demonstrating that primary and secondary unexplained infertilities are characterized by different basal sHLA-G levels and CD56+KIR2DL4+ (e)NK cell percentages.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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