Nature Communications (May 2020)
TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer
- Laura Garcia Perez,
- Jan Kempski,
- Heather M. McGee,
- Penelope Pelzcar,
- Theodora Agalioti,
- Anastasios Giannou,
- Leonie Konczalla,
- Leonie Brockmann,
- Ramez Wahib,
- Hao Xu,
- Maria Carolina Amezcua Vesely,
- Shiwa Soukou,
- Babett Steglich,
- Tanja Bedke,
- Carolin Manthey,
- Oliver Seiz,
- Björn-Philipp Diercks,
- Stylianos Gnafakis,
- Andreas H. Guse,
- Daniel Perez,
- Jakob R. Izbicki,
- Nicola Gagliani,
- Richard A. Flavell,
- Samuel Huber
Affiliations
- Laura Garcia Perez
- I. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Jan Kempski
- I. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Heather M. McGee
- Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies
- Penelope Pelzcar
- I. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Theodora Agalioti
- Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf
- Anastasios Giannou
- I. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Leonie Konczalla
- Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf
- Leonie Brockmann
- Department of Microbiology and Immunology, Columbia University
- Ramez Wahib
- Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf
- Hao Xu
- Department of Immunobiology, School of Medicine, Yale University
- Maria Carolina Amezcua Vesely
- Department of Immunobiology, School of Medicine, Yale University
- Shiwa Soukou
- I. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Babett Steglich
- I. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Tanja Bedke
- I. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Carolin Manthey
- I. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Oliver Seiz
- I. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Björn-Philipp Diercks
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf
- Stylianos Gnafakis
- Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin
- Andreas H. Guse
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf
- Daniel Perez
- Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf
- Jakob R. Izbicki
- Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf
- Nicola Gagliani
- I. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Richard A. Flavell
- Department of Immunobiology, School of Medicine, Yale University
- Samuel Huber
- I. Department of Medicine, University Medical Center Hamburg-Eppendorf
- DOI
- https://doi.org/10.1038/s41467-020-16363-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Poly-functional helper T cells can have a stronger effect than mono-functional T cells, but whether the response is qualitatively different is not clear. Here the authors show that a population of IL-17+IL-22+, but not single IL-22+, CD4+ T cells are induced by TGF-β, enriched in patients with colorectal cancer (CRC) and drive CRC progression in mice.
