Differential patterns of very high-frequency oscillations in two seizure types of the pilocarpine-induced TLE model

Fengru Guo; Yan Cui; Airui Li; Mingqi Liu; Zhaoxin Jian; Ke Chen; Dezhong Yao; Daqing Guo; Yang Xia

Brain Research Bulletin (Nov 2023)

Differential patterns of very high-frequency oscillations in two seizure types of the pilocarpine-induced TLE model

Fengru Guo,
Yan Cui,
Airui Li,
Mingqi Liu,
Zhaoxin Jian,
Ke Chen,
Dezhong Yao,
Daqing Guo,
Yang Xia

Affiliations

Fengru Guo: Department of Neurosurgery, Sichuan Provincial People’s Hospital, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu 611731, China
Yan Cui: Corresponding authors.; Department of Neurosurgery, Sichuan Provincial People’s Hospital, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu 611731, China
Airui Li: Department of Neurosurgery, Sichuan Provincial People’s Hospital, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu 611731, China
Mingqi Liu: Department of Neurosurgery, Sichuan Provincial People’s Hospital, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu 611731, China
Zhaoxin Jian: Department of Neurosurgery, Sichuan Provincial People’s Hospital, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu 611731, China
Ke Chen: Department of Neurosurgery, Sichuan Provincial People’s Hospital, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu 611731, China
Dezhong Yao: Department of Neurosurgery, Sichuan Provincial People’s Hospital, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu 611731, China
Daqing Guo: Department of Neurosurgery, Sichuan Provincial People’s Hospital, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu 611731, China
Yang Xia: Corresponding authors.; Department of Neurosurgery, Sichuan Provincial People’s Hospital, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu 611731, China

Journal volume & issue: Vol. 204
p. 110805

Abstract

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Aims: Very high-frequency oscillations (VHFOs, >500 Hz) are considered a highly sensitive biomarker of seizures. We hypothesized that VHFOs may exhibit specificity towards hypersynchronous (HYP) seizures and low-voltage fast (LVF) seizures in temporal lobe epilepsy (TLE). Methods: Local field potentials were recorded from the hippocampal network in TLE mice induced by pilocarpine. Subsequently, we analyzed the VHFO features, including their temporal-frequency characteristics and VHFO/theta coupling, during three states: baseline, preictal, and postictal for both HYP- and LVF-seizure groups. Results: Significant changes in most of the VHFO features were observed during the preictal state in both seizure groups. In the postictal state, VHFO features in the HYP-seizure group exhibited inverse alterations and appeared to align with those observed during baseline conditions. However, such phenomena were not observed after TLE seizures in the LVF-seizure group. Conclusion: Our findings highlight distinct patterns of VHFO feature changes across different states of HYP seizures and LVF seizures. These results suggest that VHFOs could serve as indicative biomarkers for seizure alterations specifically associated with HYP-seizure states

Published in Brain Research Bulletin

ISSN: 1873-2747 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.sciencedirect.com/journal/brain-research-bulletin

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