Effect of Antiacid Drugs on Absorption of Small Molecular Targeted Drugs

Abstract

Gastric juice pH is an important factor affecting the dissolution of small molecular targeted drugs (SMTD) in vivo, and the antiacid drugs (AD) can affect the solubility of SMTD by altering pH in the stomach. When the solubility is high, the absorption of the medicine is better; otherwise, if the solubility is low, the absorption of the medicine is poor. In order to investigate the effect of AD on the absorption of SMTD, electronic database were searched for the related articles. According to the related articles, it can see that dasatinib, erlotinib, gefitinib, lapatinib and nilotinib are significantly affected, which indicated that attention should be paid to the effect of AD on the absorption of SMTD, to avoid reducing the bioavailability and efficacy of SMTD.

Keywords

• antiacid drugs
• small molecular targeted drugs
• ph
• absorption
• efficacy