POSSIBILITIES OF PROLONGED BLOOD PRESSURE MONITORING IN ASSESSMENT OF THE EFFICACY AND SAFETY OF COMBINED ANTIHYPERTENSIVE THERAPY IN EMERGENCY CARE

Abstract

Introduction. At the stage of emergency medical care, the time of observation of a patient receiving antihypertensive therapy is limited to the time of stay of the emergency medical service team with this patient. Therefore, assessing the efficacy and safety of prescribing a particular antihypertensive treatment pattern is a relevant task. Patients and Methods. In this study, we used three two-component combinations of antihypertensive drugs (captopril and furosemide, moxonidine and furosemide, moxonidine and nifedipine) and prolonged blood pressure monitoring. We included 105 patients with a history of primary arterial hypertension who called an ambulance because of an increase in blood pressure and signed a voluntary informed consent. Evaluation of the results of prolonged blood pressure monitoring was carried out in 91 patients. The comorbidity, the clinical condition of the patient, blood pressure monitoring parameters, the efficacy and safety of antihypertensive therapy at the prehospital stage were evaluated. Results. The most pronounced and somewhat excessive hypotensive effect developed when using a combination of moxonidine with nifedipine. The index of excessive decrease in blood pressure below 120/70 mm Hg in this group was 51.6% (p<0.05), as compared to the combinations of captopril with furosemide and moxonidine with furosemide (10.3% and 7.8%, respectively). Conclusion. The use of blood pressure monitoring in patients with a clinically significant increase in blood pressure on prehospital stage allows us to assess the dynamics of blood pressure, the effectiveness and safety of prescribing various combinations of antihypertensive drugs.

Keywords

• arterial hypertension
• ambulance
• antihypertensive therapy
• blood pressure monitoring
• prehospital stage
• captopril
• furosemide
• moxonidine
• nifedipine