Brazilian Journal of Pharmaceutical Sciences (Dec 2013)

Analgesic and anti-inflammatory activities of several 4-substituted-6-(3'-nitrophenyl)pyridazin-(2H)-3-one derivatives

  • Anita Singh,
  • Lakshmayya,
  • Mohammad Asif

DOI
https://doi.org/10.1590/s1984-82502013000400030
Journal volume & issue
Vol. 49, no. 4
pp. 903 – 909

Abstract

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Several 6-aryl-4-substituted benzylidene/furfurylidene pyridazin(2H)-3-one derivatives (4a-f) were synthesized and evaluated as analgesic and anti-inflammatory agents in mice and rats, respectively. All compounds were tested by using Eddy's hot plate and the carrageenan-induced hind paw oedema method for the evaluation of analgesic and anti-inflammatory activities, respectively. Results showed that compounds 4f, 4b, 4d, and 4e exhibited higher analgesic and anti-inflammatory activities than other remaining compounds. All title compounds (4a-f) were characterized by IR, NMR and Mass spectroscopy.

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