Mediators of Inflammation (Jan 2001)

Effects of PDE4 inhibitors on lipopolysaccharide-induced priming of superoxide anion production from human mononuclear cells

  • Noëlla Germain,
  • Marianne Corbel,
  • Chantal Belleguic,
  • Elisabeth Boichot,
  • Vincent Lagente

DOI
https://doi.org/10.1080/09629350123856
Journal volume & issue
Vol. 10, no. 3
pp. 117 – 123

Abstract

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Aims: Phosphodiesterase 4 (PDE4) inhibitors have been described as potent anti-inflammatory compounds, involving an increase in intracellular levels of cyclic 3',5'-adenosine monophosphate (AMP). The aim of this study was to compare the effects of selective PDE4 inhibitors, rolipram and RP 73-401 with the cell permeable analogue of cyclic AMP, dibutyryl-cyclic AMP (db-cAMP) and the anti-inflammatory cytokine interleukin-10 (IL-10) on superoxide anion production from peripheral blood mononuclear cells preincubated with lipopolysaccharide (LPS).