Single-Nucleus Transcriptomic Analysis Reveals Important Cell Cross-Talk in Diabetic Kidney Disease

Yi Wei; Xiang Gao; Aihua Li; Mengjun Liang; Zongpei Jiang

doi:10.3389/fmed.2021.657956

Frontiers in Medicine (Apr 2021)

Single-Nucleus Transcriptomic Analysis Reveals Important Cell Cross-Talk in Diabetic Kidney Disease

Yi Wei,
Xiang Gao,
Aihua Li,
Mengjun Liang,
Zongpei Jiang

Affiliations

Yi Wei: Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
Xiang Gao: Department of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
Aihua Li: Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
Mengjun Liang: Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
Zongpei Jiang: Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

DOI: https://doi.org/10.3389/fmed.2021.657956
Journal volume & issue: Vol. 8

Abstract

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Diabetic kidney disease (DKD) leads to the loss of renal function and cell cross-talk is one of the crucial mechanisms participating in the pathogenesis of DKD. However, the mechanisms of cell communication were not fully elucidated in previous studies. In this study, we performed cell cross-talk analysis using CellPhoneDB based on a single-nucleus transcriptomic dataset (GSE131882) and revealed the associations between cell communication-related genes and renal function, providing overall insight into cell communication in DKD. In addition, this study may facilitate the discovery of novel mechanisms, promising biomarkers, and therapeutic targets that are clinically beneficial to patients.

Published in Frontiers in Medicine

ISSN: 2296-858X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General)
Website: http://www.frontiersin.org/journals/medicine

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Abstract

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