The differential effects of integrase strand transfer inhibitors and efavirenz on neuropsychiatric conditions and brain imaging in HIV-positive men who have sex with men

Yihui He; Yang Zhang; Jiaxin Zhen; Guangqiang Sun; Zhen Li; Bo Yang; Bin Yang; Keyi Chang; Xue Chen; Yulin Zhang; Caiping Guo; Wen Wang; Ping Wu; Tong Zhang; Lei Wang

Biosafety and Health (Aug 2024)

The differential effects of integrase strand transfer inhibitors and efavirenz on neuropsychiatric conditions and brain imaging in HIV-positive men who have sex with men

Yihui He,
Yang Zhang,
Jiaxin Zhen,
Guangqiang Sun,
Zhen Li,
Bo Yang,
Bin Yang,
Keyi Chang,
Xue Chen,
Yulin Zhang,
Caiping Guo,
Wen Wang,
Ping Wu,
Tong Zhang,
Lei Wang

Affiliations

Yihui He: Postgraduate Union Training Base of Jinzhou Medical University, PLA Rocket Force Characteristic Medical Center, Beijing 100088, China; Department of Neurology, PLA Rocket Force Characteristic Medical Center, Beijing 100088, China
Yang Zhang: Center for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China; Beijing Key Laboratory for HIV/AIDS Research, Beijing 100069, China; Beijing Institute for Sexually Transmitted Disease Control, Beijing 100069, China
Jiaxin Zhen: Center for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China; Beijing Key Laboratory for HIV/AIDS Research, Beijing 100069, China; Beijing Institute for Sexually Transmitted Disease Control, Beijing 100069, China
Guangqiang Sun: Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders and National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100069, China
Zhen Li: Center for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China; Beijing Key Laboratory for HIV/AIDS Research, Beijing 100069, China
Bo Yang: The Second Hospital of Beijing, Beijing 100031, China
Bin Yang: The Second Hospital of Beijing, Beijing 100031, China
Keyi Chang: Center for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China; Beijing Institute for Sexually Transmitted Disease Control, Beijing 100069, China
Xue Chen: Center for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China; Beijing Key Laboratory for HIV/AIDS Research, Beijing 100069, China; Beijing Institute for Sexually Transmitted Disease Control, Beijing 100069, China
Yulin Zhang: Department of Respiratory and Critical Care Medicine, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
Caiping Guo: Center for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China; Beijing Key Laboratory for HIV/AIDS Research, Beijing 100069, China; Beijing Institute for Sexually Transmitted Disease Control, Beijing 100069, China
Wen Wang: Center for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China; Beijing Key Laboratory for HIV/AIDS Research, Beijing 100069, China; Beijing Institute for Sexually Transmitted Disease Control, Beijing 100069, China
Ping Wu: National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing 100191, China; Key Discipline for Neuroscience of the Ministry of Education, Department of Neurobiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China; Corresponding authors: National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing 100191, China (P. Wu); Center for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China (T. Zhang); Department of Neurology, PLA Rocket Force Characteristic Medical Center, Beijing 100088, China (L. Wang).
Tong Zhang: Center for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China; Beijing Key Laboratory for HIV/AIDS Research, Beijing 100069, China; Beijing Institute for Sexually Transmitted Disease Control, Beijing 100069, China; Corresponding authors: National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing 100191, China (P. Wu); Center for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China (T. Zhang); Department of Neurology, PLA Rocket Force Characteristic Medical Center, Beijing 100088, China (L. Wang).
Lei Wang: Postgraduate Union Training Base of Jinzhou Medical University, PLA Rocket Force Characteristic Medical Center, Beijing 100088, China; Department of Neurology, PLA Rocket Force Characteristic Medical Center, Beijing 100088, China; Corresponding authors: National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing 100191, China (P. Wu); Center for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China (T. Zhang); Department of Neurology, PLA Rocket Force Characteristic Medical Center, Beijing 100088, China (L. Wang).

Journal volume & issue: Vol. 6, no. 4
pp. 216 – 224

Abstract

Read online

Integrase strand transfer inhibitors (INSTIs) have emerged as the first-line choice for treating human immunodeficiency virus (HIV) infection due to their superior efficacy and safety. However, the impact of INSTIs on the development of neuropsychiatric conditions in people living with HIV (PLWH) is not fully understood due to limited data. In this study, we conducted a cross-sectional examination of PLWH receiving antiretroviral therapy, with a specific focus on HIV-positive men who have sex with men (MSM) on INSTI-based regimens (n = 61) and efavirenz (EFV)-based regimens (n = 28). Participants underwent comprehensive neuropsychiatric evaluations and multimodal magnetic resonance imaging (MRI) scans, including T1-weighted images and resting-state functional MRI. Compared to the EFV group, the INSTI group exhibited primarily reduced gray matter volume (GMV) in the right superior parietal gyrus, higher regional homogeneity (ReHo) in the left postcentral gyrus, lower ReHo in the right orbital part of the inferior frontal gyrus, and increased voxel-wise functional connectivity for the seed region in the left inferior temporal gyrus with clusters in the right cuneus. Furthermore, the analysis revealed a main effect of antiretroviral drugs on GMV changes, but no main effect of neuropsychiatric disorders or their interaction. The repeated analysis of participants who did not switch regimens confirmed the GMV changes in the INSTI group, validating the initial findings. Our study demonstrated gray matter atrophy and functional brain changes in PLWH on INSTI-based regimens compared to those on EFV-based regimens. These neuroimaging results provide valuable insights into the characteristics of brain network modifications in PLWH receiving INSTI-based regimens.

Published in Biosafety and Health

ISSN: 2590-0536 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases; Medicine: Public aspects of medicine
Website: https://www.journals.elsevier.com/biosafety-and-health/

About the journal

Abstract

Keywords