How mono- and diphosphine ligands alter regioselectivity of the Rh-catalyzed annulative cleavage of bicyclo[1.1.0]butanes

Pan-Pan Chen; Peter Wipf; K. N. Houk

doi:10.1038/s41467-022-34837-x

Nature Communications (Nov 2022)

How mono- and diphosphine ligands alter regioselectivity of the Rh-catalyzed annulative cleavage of bicyclo[1.1.0]butanes

Pan-Pan Chen,
Peter Wipf,
K. N. Houk

Affiliations

Pan-Pan Chen: Department of Chemistry and Biochemistry, University of California
Peter Wipf: Department of Chemistry, University of Pittsburgh
K. N. Houk: Department of Chemistry and Biochemistry, University of California

DOI: https://doi.org/10.1038/s41467-022-34837-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 9

Abstract

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Ligands alter the regioselectivity of Rh(I)- catalyzed cycloisomerizations of bicyclobutanes. Here, mechanistic studies performed by the authors pinpoint a concerted C−C bond cleavage and carbenoid formation responsible for the divergence.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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