Structural basis of FPR2 in recognition of Aβ42 and neuroprotection by humanin

Ya Zhu; Xiaowen Lin; Xin Zong; Shuo Han; Mu Wang; Yuxuan Su; Limin Ma; Xiaojing Chu; Cuiying Yi; Qiang Zhao; Beili Wu

doi:10.1038/s41467-022-29361-x

Nature Communications (Apr 2022)

Structural basis of FPR2 in recognition of Aβ42 and neuroprotection by humanin

Ya Zhu,
Xiaowen Lin,
Xin Zong,
Shuo Han,
Mu Wang,
Yuxuan Su,
Limin Ma,
Xiaojing Chu,
Cuiying Yi,
Qiang Zhao,
Beili Wu

Affiliations

Ya Zhu: CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Xiaowen Lin: CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Xin Zong: CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Shuo Han: CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Mu Wang: CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Yuxuan Su: School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University
Limin Ma: CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Xiaojing Chu: CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Cuiying Yi: CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Qiang Zhao: CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Beili Wu: CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-022-29361-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 10

Abstract

Read online

The formyl peptide receptor 2 (FPR2) is involved in the pathogenesis of Alzheimer’s disease. Structures of FPR2 bound to Aβ42, humanin, or formyl peptides offer insight into Aβ42 neurotoxicity, humanin neuroprotection, and FPR ligand selectivity

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal