Dysregulation of NF-kB and JAK2/STAT3 signaling in the hippocampus of female WKY strain, a genetic animal model of depression

Stefanović Bojana V.; Virijević Kristina M.; Spasojević Nataša M.; Ferizović Harisa N.; Janković Milica D.; Vasljević Perica J.; Dronjak Slađana S.

Kragujevac Journal of Science (Jan 2023)

Dysregulation of NF-kB and JAK2/STAT3 signaling in the hippocampus of female WKY strain, a genetic animal model of depression

Stefanović Bojana V.,
Virijević Kristina M.,
Spasojević Nataša M.,
Ferizović Harisa N.,
Janković Milica D.,
Vasljević Perica J.,
Dronjak Slađana S.

Affiliations

Stefanović Bojana V.: University of Belgrade, "VINČA" Institute of Nuclear Sciences - National Institute of the Republic of Serbia, Department of Molecular Biology and Endocrinology, Belgrade, Serbia
Virijević Kristina M.: University of Belgrade, "VINČA" Institute of Nuclear Sciences - National Institute of the Republic of Serbia, Department of Molecular Biology and Endocrinology, Belgrade, Serbia
Spasojević Nataša M.: ORCiD; University of Belgrade, "VINČA" Institute of Nuclear Sciences - National Institute of the Republic of Serbia, Department of Molecular Biology and Endocrinology, Belgrade, Serbia
Ferizović Harisa N.: University of Belgrade, "VINČA" Institute of Nuclear Sciences - National Institute of the Republic of Serbia, Department of Molecular Biology and Endocrinology, Belgrade, Serbia
Janković Milica D.: University of Belgrade, "VINČA" Institute of Nuclear Sciences - National Institute of the Republic of Serbia, Department of Molecular Biology and Endocrinology, Belgrade, Serbia
Vasljević Perica J.: University of Nis, Faculty of Sciences and Mathematics, Department of Biology and Ecology, Niš, Serbia
Dronjak Slađana S.: ORCiD; University of Belgrade, "VINČA" Institute of Nuclear Sciences - National Institute of the Republic of Serbia, Department of Molecular Biology and Endocrinology, Belgrade, Serbia

Journal volume & issue: Vol. 2023, no. 45
pp. 149 – 158

Abstract

Read online

Depression is a serious disorder with a large impact on both an individual's quality of life and society as a whole. This study aimed to evaluate the potential involvement of nuclear factor kappa-B (NF-kB) and the Janus activated kinase (JAK) and Signal transducer and activator of transcription proteins (STAT) signaling pathway in the pathogenesis of genetically predisposed depression in female rats. The obtained results showed increased phosphorylation in JAK2 and STAT3, and increased protein levels of NF-kB in the hippocampus of Wistar Kyoto rats compared to Wistar rats. These results suggest that disturbance in these pathways could have a significant role in the pathophysiology of genetically predisposed depression in females.

Published in Kragujevac Journal of Science

ISSN: 1450-9636 (Print); 2466-5509 (Online)
Publisher: University of Kragujevac, Faculty of Science
Country of publisher: Serbia
LCC subjects: Science
Website: http://scindeks.ceon.rs/journalDetails.aspx?issn=1450-9636&lang=en

About the journal

Abstract

Keywords