Evolving Roles of Natural Terpenoids From Traditional Chinese Medicine in the Treatment of Osteoporosis

Yue Zhuo; Meng Li; Qiyao Jiang; Hanzhong Ke; Qingchun Liang; Ling-Feng Zeng; Jiansong Fang

doi:10.3389/fendo.2022.901545

Frontiers in Endocrinology (May 2022)

Evolving Roles of Natural Terpenoids From Traditional Chinese Medicine in the Treatment of Osteoporosis

Yue Zhuo,
Meng Li,
Qiyao Jiang,
Hanzhong Ke,
Qingchun Liang,
Ling-Feng Zeng,
Jiansong Fang

Affiliations

Yue Zhuo: Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China
Meng Li: Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Women and Children’s Medical Center, Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Guangzhou Medical University, Guangzhou, China
Qiyao Jiang: Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China
Hanzhong Ke: Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States
Qingchun Liang: The Third Affiliated Hospital of Southern Medical University, Guangzhou, China
Ling-Feng Zeng: The 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Jiansong Fang: Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China

DOI: https://doi.org/10.3389/fendo.2022.901545
Journal volume & issue: Vol. 13

Abstract

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Osteoporosis (OP) is a systemic metabolic skeletal disease which can lead to reduction in bone mass and increased risk of bone fracture due to the microstructural degradation. Traditional Chinese medicine (TCM) has been applied in the prevention and treatment of osteoporosis for a long time. Terpenoids, a class of natural products that are rich in TCM, have been widely studied for their therapeutic efficacy on bone resorption, osteogenesis, and concomitant inflammation. Terpenoids can be classified in four categories by structures, monoterpenoids, sesquiterpenoids, diterpenoids, and triterpenoids. In this review, we comprehensively summarize all the currently known TCM-derived terpenoids in the treatment of OP. In addition, we discuss the possible mechanistic-of-actions of all four category terpenoids in anti-OP and assess their therapeutic potential for OP treatment.

Published in Frontiers in Endocrinology

ISSN: 1664-2392 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://www.frontiersin.org/journals/endocrinology

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Abstract

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