MMP-9 Level Comparation between Spontaneous Abortion and Normal Pregnancy

Abstract

BACKGROUND: Abortion remains a problem in the obstetric care as it is one of the causes of maternal and fetal death. Bleeding or miscarriage threat in the first trimester comprises 20% to 25% of all pregnant women, and 50% of them will end as spontaneous abortion. The major cause of maternal death in abortion is hemorrhage. Some recent studies have indicated that MMP-9 is important in the process of embryo implantation into the endometrium and spontaneous abortion occurs when there is an overwhelming increase of MMP-9. This data indicate the importance of a further research to elucidate the role of MMP-9 in spontaneous abortion. METHODS: This was a cross sectional study, included 70 pregnant women with gestational age 1221.7 with the sensitivity of 48.6% specificity of 80%, and accuracy of 60.9%. SUMMARY: The MMP-9 level in spontaneous abortion was higher than in normal pregnancy. KEYWORDS: MMP-9, spontaneous abortion, normal pregnancy.