Nature Communications (Jul 2016)
Deletion of Wiskott–Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells
- Marisa A. P. Baptista,
- Marton Keszei,
- Mariana Oliveira,
- Karen K. S. Sunahara,
- John Andersson,
- Carin I. M. Dahlberg,
- Austen J. Worth,
- Agne Liedén,
- I-Chun Kuo,
- Robert P. A. Wallin,
- Scott B. Snapper,
- Liv Eidsmo,
- Annika Scheynius,
- Mikael C. I. Karlsson,
- Gerben Bouma,
- Siobhan O. Burns,
- Mattias N. E. Forsell,
- Adrian J. Thrasher,
- Susanne Nylén,
- Lisa S. Westerberg
Affiliations
- Marisa A. P. Baptista
- Department of Microbiology Tumor and Cell biology, Karolinska Institutet
- Marton Keszei
- Department of Microbiology Tumor and Cell biology, Karolinska Institutet
- Mariana Oliveira
- Department of Microbiology Tumor and Cell biology, Karolinska Institutet
- Karen K. S. Sunahara
- Department of Microbiology Tumor and Cell biology, Karolinska Institutet
- John Andersson
- Department of Medicine Solna, Translational Immunology Unit, Karolinska Institutet and Karolinska University Hospital
- Carin I. M. Dahlberg
- Department of Microbiology Tumor and Cell biology, Karolinska Institutet
- Austen J. Worth
- University College London Institute of Child Health
- Agne Liedén
- Department of Molecular Medicine and Surgery, Karolinska Institutet
- I-Chun Kuo
- Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore
- Robert P. A. Wallin
- Department of Microbiology Tumor and Cell biology, Karolinska Institutet
- Scott B. Snapper
- Gastroenterology Division, Children's Hospital, Harvard Medical School
- Liv Eidsmo
- Department of Medicine Solna, Dermatology and Venereology Unit, Karolinska Institutet
- Annika Scheynius
- Department of Medicine Solna, Translational Immunology Unit, Karolinska Institutet and Karolinska University Hospital
- Mikael C. I. Karlsson
- Department of Microbiology Tumor and Cell biology, Karolinska Institutet
- Gerben Bouma
- University College London Institute of Child Health
- Siobhan O. Burns
- University College London Institute of Child Health
- Mattias N. E. Forsell
- Department of Microbiology Tumor and Cell biology, Karolinska Institutet
- Adrian J. Thrasher
- University College London Institute of Child Health
- Susanne Nylén
- Department of Microbiology Tumor and Cell biology, Karolinska Institutet
- Lisa S. Westerberg
- Department of Microbiology Tumor and Cell biology, Karolinska Institutet
- DOI
- https://doi.org/10.1038/ncomms12175
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 15
Abstract
Wiskott–Aldrich syndrome (WAS) is a severe X-linked primary immunodeficiency syndrome. Here, the authors show that loss of WAS gene in dendritic cells results in increased activity of Rac2, increase of phagosomal pH, and more efficient cross-presentation.
