Nature Communications (Feb 2018)

Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration

  • Wei Huang,
  • Yuliang Feng,
  • Jialiang Liang,
  • Hao Yu,
  • Cheng Wang,
  • Boyu Wang,
  • Mingyang Wang,
  • Lin Jiang,
  • Wei Meng,
  • Wenfeng Cai,
  • Mario Medvedovic,
  • Jenny Chen,
  • Christian Paul,
  • W. Sean Davidson,
  • Sakthivel Sadayappan,
  • Peter J. Stambrook,
  • Xi-Yong Yu,
  • Yigang Wang

DOI
https://doi.org/10.1038/s41467-018-03019-z
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 16

Abstract

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During early postnatal development in mammals, cardiomyocytes exit the cell cycle, losing their regenerative capacity. Here the authors show that, following myocardial infarction, loss of microRNA-128 promotes cardiomyocyte proliferation and cardiac regeneration in adult mice partly via enhancing the expression of the chromatin modifier SUZ12.