Nature Communications (Oct 2016)
A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways
- Tianzhi Huang,
- Angel A. Alvarez,
- Rajendra P. Pangeni,
- Craig M. Horbinski,
- Songjian Lu,
- Sung-Hak Kim,
- C. David James,
- Jeffery J. Raizer,
- John A. Kessler,
- Cameron W. Brenann,
- Erik P. Sulman,
- Gaetano Finocchiaro,
- Ming Tan,
- Ryo Nishikawa,
- Xinghua Lu,
- Ichiro Nakano,
- Bo Hu,
- Shi-Yuan Cheng
Affiliations
- Tianzhi Huang
- Department of Neurology, Northwestern Brain Tumor Institute, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine
- Angel A. Alvarez
- Department of Neurology, Northwestern Brain Tumor Institute, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine
- Rajendra P. Pangeni
- Department of Neurology, Northwestern Brain Tumor Institute, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine
- Craig M. Horbinski
- Department of Neurological Surgery, Northwestern Brain Tumor Institute, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine
- Songjian Lu
- Department of Biomedical Informatics, University of Pittsburgh
- Sung-Hak Kim
- Department of Neurosurgery, University of Alabama at Birmingham
- C. David James
- Department of Neurological Surgery, Northwestern Brain Tumor Institute, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine
- Jeffery J. Raizer
- Department of Neurology, Northwestern Brain Tumor Institute, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine
- John A. Kessler
- Department of Neurology, Northwestern Brain Tumor Institute, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine
- Cameron W. Brenann
- Department of Neurosurgery, Human Oncology and Pathogenesis Program, Brain Tumor Center, Memorial Sloan-Kettering Cancer Center
- Erik P. Sulman
- Department of Radiation Oncology, The University of Texas M.D. Anderson Cancer Center
- Gaetano Finocchiaro
- Department of Neuro-Oncology, Unit of Molecular Neuro-Oncology, Fondazione IRCCS Istituto Neurologico, Via Celoria 11
- Ming Tan
- Mitchell Cancer Institute, University of South Alabama
- Ryo Nishikawa
- Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center
- Xinghua Lu
- Department of Biomedical Informatics, University of Pittsburgh
- Ichiro Nakano
- Department of Neurosurgery, University of Alabama at Birmingham
- Bo Hu
- Department of Neurology, Northwestern Brain Tumor Institute, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine
- Shi-Yuan Cheng
- Department of Neurology, Northwestern Brain Tumor Institute, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine
- DOI
- https://doi.org/10.1038/ncomms12885
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 16
Abstract
Glioblastoma (GBM) is classified as proneural (PN), neural, mesenchymal (MES) and classical GBM. Here the authors show that Wnt signalling, miR-125b and miR-20b establish a regulatory circuitry including FZD6 which distinguishes PN from the MES subtype.
