Advances in antitumor effects of NSAIDs

Abstract

Zhen Zhang,1,2 Fulin Chen,1,2 Lijun Shang1–3 1Laboratory of Tissue Engineering, Faculty of Life Science, Northwest University, Xi’an, Shaanxi Province 710069, People’s Republic of China; 2Provincial Key Laboratory of Biotechnology of Shaanxi, Northwest University, Xi’an, Shaanxi Province 710069, People’s Republic of China; 3School of Chemistry and Biosciences, Faculty of Life Sciences, University of Bradford, Bradford, UK Abstract: In recent years, the reports on using nonsteroidal anti-inflammatory drugs (NSAIDs) for cancer prevention and treatment have been on the rise. In 2017, the US Preventive Services Working Group issued primary prevention guidelines on the use of NSAIDs, especially aspirin, for cardiovascular disease and colorectal cancer, and formally established the role and status of aspirin in cancer prevention. However, the mechanism of NSAIDs on preventing cancer is still not clear. In this paper, the progress of the application of NSAIDs, especially aspirin, in the prevention and treatment of tumors in recent years is summarized, and new ideas and directions for the follow-up study are also discussed. Keywords: NSAIDs, aspirin, platelets, cancer

Keywords

• nanoparticles
• heart failure
• post-infarct ventricular remodeling