Analysis of <i>LRRN3</i>, <i>MEF2C</i>, <i>SLC22A</i>, and <i>P2RY12</i> Gene Expression in the Peripheral Blood of Patients in the Early Stages of Parkinson’s Disease
Marina V. Shulskaya,
Ekaterina I. Semenova,
Margarita M. Rudenok,
Suzanna A. Partevian,
Maria V. Lukashevich,
Alexei V. Karabanov,
Ekaterina Yu. Fedotova,
Sergey N. Illarioshkin,
Petr A. Slominsky,
Maria I. Shadrina,
Anelya Kh. Alieva
Affiliations
Marina V. Shulskaya
Laboratory of Molecular Genetics of Hereditary Diseases, National Research Center “Kurchatov Institute”, Kurchatova pl., 2, Moscow 123082, Russia
Ekaterina I. Semenova
Laboratory of Molecular Genetics of Hereditary Diseases, National Research Center “Kurchatov Institute”, Kurchatova pl., 2, Moscow 123082, Russia
Margarita M. Rudenok
Laboratory of Molecular Genetics of Hereditary Diseases, National Research Center “Kurchatov Institute”, Kurchatova pl., 2, Moscow 123082, Russia
Suzanna A. Partevian
Laboratory of Molecular Genetics of Hereditary Diseases, National Research Center “Kurchatov Institute”, Kurchatova pl., 2, Moscow 123082, Russia
Maria V. Lukashevich
Laboratory of Molecular Genetics of Hereditary Diseases, National Research Center “Kurchatov Institute”, Kurchatova pl., 2, Moscow 123082, Russia
Alexei V. Karabanov
Federal State Scientific Institution, Scientific Center of Neurology, Russian Academy of Sciences (RAS), Volokolamskoye sh., 80, Moscow 125367, Russia
Ekaterina Yu. Fedotova
Federal State Scientific Institution, Scientific Center of Neurology, Russian Academy of Sciences (RAS), Volokolamskoye sh., 80, Moscow 125367, Russia
Sergey N. Illarioshkin
Federal State Scientific Institution, Scientific Center of Neurology, Russian Academy of Sciences (RAS), Volokolamskoye sh., 80, Moscow 125367, Russia
Petr A. Slominsky
Laboratory of Molecular Genetics of Hereditary Diseases, National Research Center “Kurchatov Institute”, Kurchatova pl., 2, Moscow 123082, Russia
Maria I. Shadrina
Laboratory of Molecular Genetics of Hereditary Diseases, National Research Center “Kurchatov Institute”, Kurchatova pl., 2, Moscow 123082, Russia
Anelya Kh. Alieva
Laboratory of Molecular Genetics of Hereditary Diseases, National Research Center “Kurchatov Institute”, Kurchatova pl., 2, Moscow 123082, Russia
Parkinson’s disease (PD) is one of the most common human neurodegenerative diseases. Belated diagnoses of PD and late treatment are caused by its elongated prodromal phase. Thus, searching for new candidate genes participating in the development of the pathological process in the early stages of the disease in patients who have not yet received therapy is relevant. Changes in mRNA and protein levels have been described both in the peripheral blood and in the brain of patients with PD. Thus, analysis of changes in the mRNA expression in peripheral blood is of great importance in studying the early stages of PD. This work aimed to analyze the changes in MEF2C, SLC22A4, P2RY12, and LRRN3 gene expression in the peripheral blood of patients in the early stages of PD. We found a statistically relevant and PD-specific change in the expression of the LRRN3 gene, indicating a disruption in the processes of neuronal regeneration and the functioning of synapses. The data obtained during the study indicate that this gene can be considered a potential biomarker of the early stages of PD.
