Marine Drugs (May 2011)

Balticolid: A New 12-Membered Macrolide with Antiviral Activity from an Ascomycetous Fungus of Marine Origin

  • Ulrike Lindequist,
  • Rajinder Singh,
  • Muftah A. M. Shushni,
  • Renate Mentel

DOI
https://doi.org/10.3390/md9050844
Journal volume & issue
Vol. 9, no. 5
pp. 844 – 851

Abstract

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A new 12-membered macrolide, balticolid (1) was isolated from the EtOAc extract of the culture broth of fungal strain 222 belonging to the Ascomycota, which was found on driftwood collected from the coast of the Greifswalder Bodden, Baltic Sea, Germany. The structure of balticolid was determined to be (3R,11R), (4E,8E)-3-hydroxy-11-methyloxacyclododeca-4,8-diene-1,7-dione using extensive spectral data as well as the modified Mosher ester method. Balticolid (1) displayed anti-HSV-1 activity with an IC50 value of 0.45 µM.

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