γ-Fe2O3@Poly(sucrose allyl ether) magnetic microspheres for tumor enhanced magnetic resonance imaging and high-efficiency cooperative magnetothermal therapy

Abstract

Traditional magnetothermal nanoparticles showed great limitations for the diagnosis of tumor location in a dynamic physiological environment in vivo. Here, we show an one-step photo-click method based on the composite structure of γ-Fe2O3@Poly(sucrose allyl ether) magnetic microspheres to meet this challenge. The advantages are to prepare the magnetic microspheres not in extreme conditions and using sucrose as the polymeric matrix to prevent Fe2O3 nanoparticles from agglomeration. A series of in vitro and in vivo experiments showed that γ-Fe2O3@PSAE has excellent stability in biological medium and inappreciable cytotoxicity. Moreover obvious tumor magnetic resonance imaging contrasts were observed based on response of γ-Fe2O3@PSAE. Under an alternating magnetic field, the heat generated by the magnetic microspheres γ-Fe2O3@PSAE thermally ablated H22 hepatoma cells from Kunming male mice, thereby inhibiting tumors. The histopathological studies showed that the tumor growth was significantly inhibited with the increase in the dosage of γ-Fe2O3@PSAE.

Keywords

• Sucrose allyl ether
• Magnetic microsphere
• Magnetic resonance imaging
• Magnetothermal therapy