EClinicalMedicine (May 2024)
Decoding the historical tale: COVID-19 impact on haematological malignancy patients—EPICOVIDEHA insights from 2020 to 2022Research in context
- Jon Salmanton-García,
- Francesco Marchesi,
- Francesca Farina,
- Barbora Weinbergerová,
- Federico Itri,
- Julio Dávila-Valls,
- Sonia Martín-Pérez,
- Andreas Glenthøj,
- Ditte Stampe Hersby,
- Maria Gomes da Silva,
- Raquel Nunes Rodrigues,
- Alberto López-García,
- Raúl Córdoba,
- Yavuz M. Bilgin,
- Iker Falces-Romero,
- Shaimaa El-Ashwah,
- Ziad Emarah,
- Caroline Besson,
- Milena Kohn,
- Jaap Van Doesum,
- Emanuele Ammatuna,
- Monia Marchetti,
- Jorge Labrador,
- Giovanni Paolo Maria Zambrotta,
- Luisa Verga,
- Ozren Jaksic,
- Marcio Nucci,
- Klára Piukovics,
- Alba Cabirta-Touzón,
- Moraima Jiménez,
- Elena Arellano,
- Ildefonso Espigado,
- Ola Blennow,
- Anna Nordlander,
- Stef Meers,
- Jens van Praet,
- Tommaso Francesco Aiello,
- Carolina Garcia-Vidal,
- Nicola Fracchiolla,
- Mariarita Sciumè,
- Guldane Cengiz Seval,
- Pavel Žák,
- Caterina Buquicchio,
- Carlo Tascini,
- Stefanie K. Gräfe,
- Martin Schönlein,
- Tatjana Adžić-Vukičević,
- Valentina Bonuomo,
- Chiara Cattaneo,
- Summiya Nizamuddin,
- Martin Čerňan,
- Gaëtan Plantefeve,
- Romane Prin,
- Tomas Szotkovski,
- Graham P. Collins,
- Michelina Dargenio,
- Verena Petzer,
- Dominik Wolf,
- Natasha Čolović,
- Lucia Prezioso,
- Toni Valković,
- Francesco Passamonti,
- Gustavo-Adolfo Méndez,
- Uluhan Sili,
- Antonio Vena,
- Martina Bavastro,
- Alessandro Limongelli,
- Rafael F. Duarte,
- Marie-Pierre Ledoux,
- Milche Cvetanoski,
- Zlate Stojanoski,
- Marina Machado,
- Josip Batinić,
- Gabriele Magliano,
- Monika M. Biernat,
- Nikola Pantić,
- Christian Bjørn Poulsen,
- Annarosa Cuccaro,
- Maria Ilaria Del Principe,
- Austin Kulasekararaj,
- Irati Ormazabal-Vélez,
- Alessandro Busca,
- Fatih Demirkan,
- Marriyam Ijaz,
- Nikolai Klimko,
- Igor Stoma,
- Sofya Khostelidi,
- Noemí Fernández,
- Ali S. Omrani,
- Rui Bergantim,
- Nick De Jonge,
- Guillemette Fouquet,
- Milan Navrátil,
- Ghaith Abu-Zeinah,
- Michail Samarkos,
- Johan Maertens,
- Cristina De Ramón,
- Anna Guidetti,
- Ferenc Magyari,
- Tomás José González-López,
- Tobias Lahmer,
- Olimpia Finizio,
- Natasha Ali,
- László Imre Pinczés,
- Esperanza Lavilla-Rubira,
- Alessandra Romano,
- Maria Merelli,
- Mario Delia,
- Maria Calbacho,
- Joseph Meletiadis,
- Darko Antić,
- José-Ángel Hernández-Rivas,
- Joyce Marques de Almeida,
- Murtadha Al-Khabori,
- Martin Hoenigl,
- Maria Chiara Tisi,
- Nina Khanna,
- Aleksandra Barać,
- Noha Eisa,
- Roberta Di Blasi,
- Raphaël Liévin,
- Carolina Miranda-Castillo,
- Nathan C. Bahr,
- Sylvain Lamure,
- Mario Virgilio Papa,
- Ayel Yahya,
- Avinash Aujayeb,
- Jan Novák,
- Nurettin Erben,
- María Fernández-Galán,
- José-María Ribera-Santa Susana,
- Ikhwan Rinaldi,
- Rita Fazzi,
- Monica Piedimonte,
- Rémy Duléry,
- Yung Gonzaga,
- Andrés Soto-Silva,
- Giuseppe Sapienza,
- Alexandra Serris,
- Ľuboš Drgoňa,
- Ana Groh,
- Laura Serrano,
- Eleni Gavriilaki,
- Athanasios Tragiannidis,
- Juergen Prattes,
- Nicola Coppola,
- Vladimir Otašević,
- Miloš Mladenović,
- Mirjana Mitrović,
- Bojana Mišković,
- Pavel Jindra,
- Sofia Zompi,
- Maria Vittoria Sacchi,
- Carolin Krekeler,
- Maria Stefania Infante,
- Daniel García-Bordallo,
- Gökçe Melis Çolak,
- Jiří Mayer,
- Marietta Nygaard,
- Michaela Hanáková,
- Zdeněk Ráčil,
- Matteo Bonanni,
- Philipp Koehler,
- Laman Rahimli,
- Oliver A. Cornely,
- Livio Pagano,
- Francisco Javier Martín-Vallejo,
- Przemyslaw Zdziarski,
- Hossein Zarrinfer,
- Jana Wittig,
- Sein Win,
- Vivien Wai-Man,
- Benjamín Víšek,
- Donald C. Vinh,
- Maria Vehreschild,
- Gina Varricchio,
- Panagiotis Tsirigotis,
- Ana Torres-Tienza,
- Alina Daniela Tanase,
- Agostino Tafuri,
- Maria Stamouli,
- Jiří Sramek,
- Carole Soussain,
- Ayten Shirinova,
- Jörg Schubert,
- Enrico Schalk,
- Mohammad Reza Salehi,
- Modar Saleh,
- Giorgio Rosati,
- Elisa Roldán,
- Florian Reizine,
- Mayara Rêgo,
- Isabel Regalado-Artamendi,
- Marina Popova,
- Fernando Pinto,
- Laure Philippe,
- Hans Martin Orth,
- Hans-Beier Ommen,
- Aleš Obr,
- Lucía Núñez-Martín-Buitrago,
- Nicolas Noël,
- Julia Neuhann,
- Gianpaolo Nadali,
- Julia A. Nacov,
- Ana M. Munhoz Alburquerque,
- Maria Enza Mitra,
- Malgorzata Mikulska,
- Sibylle Mellinghoff,
- Ben Mechtel,
- Juan-Alberto Martín-González,
- Sandra Malak,
- Jorge Loureiro-Amigo,
- Lisset Lorenzo De La Peña,
- Giulia Liberti,
- Marianne Landau,
- Ira Lacej,
- Martin Kolditz,
- Chi Shan Kho,
- Reham Abdelaziz Khedr,
- Meinolf Karthaus,
- Linda Katharina Karlsson,
- María-Josefa Jiménez-Lorenzo,
- Macarena Izuzquiza,
- Baerbel Hoell-Neugebauer,
- Raoul Herbrecht,
- Christopher H. Heath,
- Fabio Guolo,
- Jan Grothe,
- Antonio Giordano,
- Sergey Gerasymchuk,
- Ramón García-Sanz,
- Nicole García-Poutón,
- Vaneuza Araújo Moreira Funke,
- Monica Fung,
- Charlotte Flasshove,
- Luana Fianchi,
- Jenna Essame,
- Matthias Egger,
- Bernard Drenou,
- Giulia Dragonetti,
- Maximilian Desole,
- Roberta Della Pepa,
- Bénédicte Deau Fischer,
- Elizabeth De Kort,
- Erik De Cabo,
- François Danion,
- Etienne Daguindau,
- Tania Cushion,
- Louise Cremer,
- Marianna Criscuolo,
- Gregorio Cordini,
- Antonella Cingolani,
- Fabio Ciceri,
- Fazle Rabbi Chowdhury,
- Ekaterina Chelysheva,
- Adrien Chauchet,
- Louis Yi Ann Chai,
- M. Mansour Ceesay,
- Elena Busch,
- Mathias Brehon,
- Davimar M.M. Borducchi,
- Stephen Booth,
- Serge Bologna,
- Caroline Berg Venemyr,
- Rebeca Bailén-Almorox,
- Anastasia Antoniadou,
- Amalia N. Anastasopoulou,
- Fevzi Altuntaş
Affiliations
- Jon Salmanton-García
- University of Cologne, Faculty of Medicine, and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany; University of Cologne, Faculty of Medicine, University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), Cologne, Germany; German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany; Corresponding author. University of Cologne, Faculty of Medicine and University Hospital Cologne, Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Herderstrasse 52, Cologne 50931, Germany.
- Francesco Marchesi
- Hematology and Stem Cell Transplant Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy
- Francesca Farina
- IRCCS Ospedale San Raffaele, Milan, Italy
- Barbora Weinbergerová
- Masaryk University and University Hospital Brno - Department of Internal Medicine, Hematology and Oncology, Brno, Czech Republic
- Federico Itri
- San Luigi Gonzaga Hospital - Orbassano, Orbassano, Italy
- Julio Dávila-Valls
- Hospital Nuestra Señora de Sonsoles, Ávila, Spain
- Sonia Martín-Pérez
- Hospital Nuestra Señora de Sonsoles, Ávila, Spain
- Andreas Glenthøj
- Department of Hematology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
- Ditte Stampe Hersby
- Department of Hematology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
- Maria Gomes da Silva
- Portuguese Institute of Oncology, Lisbon, Portugal
- Raquel Nunes Rodrigues
- Portuguese Institute of Oncology, Lisbon, Portugal
- Alberto López-García
- Fundación Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, Madrid, Spain
- Raúl Córdoba
- Fundación Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, Madrid, Spain
- Yavuz M. Bilgin
- Department of Internal Medicine, ADRZ, Goes, Netherlands
- Iker Falces-Romero
- Microbiology and Parasitology Department, University Hospital La Paz, Madrid, Spain; CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain
- Shaimaa El-Ashwah
- Oncology Center, Mansoura University, Mansoura, Egypt
- Ziad Emarah
- Oncology Center, Mansoura University, Mansoura, Egypt; King Abdullah Medical City, Makkah, Saudi Arabia
- Caroline Besson
- Centre Hospitalier de Versailles, Le Chesnay, France; Université Paris-Saclay, UVSQ, Inserm, Équipe “Exposome et Hérédité”, CESP, Villejuif, France
- Milena Kohn
- Centre Hospitalier de Versailles, Le Chesnay, France; Université Paris-Saclay, UVSQ, Inserm, Équipe “Exposome et Hérédité”, CESP, Villejuif, France
- Jaap Van Doesum
- University Medical Center Groningen, Groningen, Netherlands
- Emanuele Ammatuna
- University Medical Center Groningen, Groningen, Netherlands
- Monia Marchetti
- Hematology and Transplant Unit, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy
- Jorge Labrador
- Department of Hematology, Research Unit, Hospital Universitario de Burgos, Burgos, Spain
- Giovanni Paolo Maria Zambrotta
- Azienda Ospedaliera San Gerardo - Monza, Monza, Italy; Università Milano-Bicocca, Milan, Italy
- Luisa Verga
- Azienda Ospedaliera San Gerardo - Monza, Monza, Italy; Università Milano-Bicocca, Milan, Italy
- Ozren Jaksic
- University Hospital Dubrava, Zagreb, Croatia
- Marcio Nucci
- Department of Internal Medicine, Federal University of Rio de Janeiro and Grupo Oncoclinicas, Rio de Janeiro, Brazil
- Klára Piukovics
- Department of Internal Medicine, South Division Faculty of Medicine University of Szeged, Szeged, Hungary
- Alba Cabirta-Touzón
- Department of Hematology, Vall d’Hebron Hospital Universitari, Experimental Hematology, Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain
- Moraima Jiménez
- Department of Hematology, Vall d’Hebron Hospital Universitari, Experimental Hematology, Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain
- Elena Arellano
- Department of Hematology, University Hospital Virgen Macarena - University Hospital Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS/CSIC), Universidad de Sevilla (Departamento de Medicina), Seville, Spain
- Ildefonso Espigado
- Department of Hematology, University Hospital Virgen Macarena - University Hospital Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS/CSIC), Universidad de Sevilla (Departamento de Medicina), Seville, Spain
- Ola Blennow
- Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden
- Anna Nordlander
- Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden
- Stef Meers
- AZ KLINA, Brasschaat, Belgium
- Jens van Praet
- Department of Nephrology and Infectious diseases, AZ Sint-Jan Brugge-Oostende AV, Brugge, Belgium
- Tommaso Francesco Aiello
- Department of Infectious Diseases, Hospital Clinic de Barcelona, University of Barcelona, IDIBAPS, Barcelona, Spain
- Carolina Garcia-Vidal
- Department of Infectious Diseases, Hospital Clinic de Barcelona, University of Barcelona, IDIBAPS, Barcelona, Spain
- Nicola Fracchiolla
- Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
- Mariarita Sciumè
- Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
- Guldane Cengiz Seval
- Ankara University, Ankara, Turkey
- Pavel Žák
- University Hospital Hradec Králové, Hradec Králové, Czech Republic
- Caterina Buquicchio
- Ematologia con Trapianto, Ospedale Dimiccoli Barletta, Barletta, Italy
- Carlo Tascini
- Azienda Sanitaria Universitaria del Friuli Centrale, Udine, Italy
- Stefanie K. Gräfe
- University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- Martin Schönlein
- Department of Oncology, Hematology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- Tatjana Adžić-Vukičević
- COVID Hospital “Batajnica”, Belgrade, Serbia
- Valentina Bonuomo
- Policlinico Borgo Roma Verona, Verona, Italy
- Chiara Cattaneo
- Hematology Unit, ASST-Spedali Civili, Brescia, Italy
- Summiya Nizamuddin
- Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
- Martin Čerňan
- University Hospital Olomouc, Olomouc, Czech Republic
- Gaëtan Plantefeve
- Head ICU and CRC, Centre Hospitalier Victor DUPOUY, Argenteuil, France
- Romane Prin
- CRA from CRC Centre Hospitalier Victor DUPOUY, Argenteuil, France
- Tomas Szotkovski
- University Hospital Olomouc, Olomouc, Czech Republic
- Graham P. Collins
- Oxford University Hospitals, Oxford, United Kingdom
- Michelina Dargenio
- Ospedale Vito Fazzi, Lecce, Italy
- Verena Petzer
- Department of Hematology and Oncology, Comprehensive Cancer Center Innsbruck (CCCI), Medical University of Innsbruck (MUI), Innsbruck, Austria
- Dominik Wolf
- Department of Hematology and Oncology, Comprehensive Cancer Center Innsbruck (CCCI), Medical University of Innsbruck (MUI), Innsbruck, Austria
- Natasha Čolović
- University Clinical Center Serbia, Belgrade, Serbia
- Lucia Prezioso
- Hospital University of Parma - Hematology and Bone Marrow Unit, Parma, Italy
- Toni Valković
- University Hospital Centre Rijeka, Rijeka, Croatia; Croatian Cooperative Group for Hematological Diseases (CROHEM), Croatia; Faculty of Medicine and Faculty of Health Studies of University of Rijeka, Rijeka, Croatia
- Francesco Passamonti
- Department of Medicine and Surgery, University of Insubria and ASST Sette Laghi, Ospedale di Circolo of Varese, Varese, Italy
- Gustavo-Adolfo Méndez
- Hospital Escuela de Agudos Dr. Ramón Madariaga, Posadas, Argentina
- Uluhan Sili
- Department of Infectious Diseases and Clinical Microbiology, School of Medicine, Marmara University, Istanbul, Turkey
- Antonio Vena
- Ospedale Policlinico San Martino, Genoa, Italy
- Martina Bavastro
- Ospedale Policlinico San Martino, Genoa, Italy
- Alessandro Limongelli
- Ospedale Policlinico San Martino, Genoa, Italy
- Rafael F. Duarte
- Hospital Universitario Puerta de Hierro, Majadahonda, Spain
- Marie-Pierre Ledoux
- ICANS, Strasbourg, France
- Milche Cvetanoski
- University Clinic of Hematology, Skopje, North Macedonia
- Zlate Stojanoski
- University Clinic of Hematology, Skopje, North Macedonia
- Marina Machado
- Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain
- Josip Batinić
- Croatian Cooperative Group for Hematological Diseases (CROHEM), Croatia; University Hospital Centre Zagreb, Zagreb, Croatia; Faculty of Medicine University of Zagreb, Zagreb, Croatia
- Gabriele Magliano
- ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy
- Monika M. Biernat
- Wroclaw Medical University, Wroclaw, Poland
- Nikola Pantić
- University Clinical Center of Serbia, Belgrade, Serbia
- Christian Bjørn Poulsen
- Zealand University Hospital, Roskilde, Denmark
- Annarosa Cuccaro
- Hematology Unit, Center for Translational Medicine, Azienda USL Toscana NordOvest, Livorno, Italy; National Cancer Institute, Fondazione ‘G. Pascale’, IRCCS, Hematology-Oncology and Stem Cell Transplantation Unit, Naples, Italy
- Maria Ilaria Del Principe
- Hematology, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
- Austin Kulasekararaj
- Department of Hematological Medicine, King's College Hospital NHS Foundation Trust, London, United Kingdom
- Irati Ormazabal-Vélez
- Hospital Universitario de Navarra, Iruña-Pamplona, Spain
- Alessandro Busca
- Stem Cell Transplant Center, AOU Citta’ della Salute e della Scienza, Turin, Italy
- Fatih Demirkan
- Dokuz Eylul University, Division of Hematology, Izmir, Turkey
- Marriyam Ijaz
- Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
- Nikolai Klimko
- North-Western State Medical University Named after Iliá Ilich Méchnikov, Saint-Petersburg, Russia
- Igor Stoma
- Gomel State Medical University, Gomel, Belarus
- Sofya Khostelidi
- North-Western State Medical University Named after Iliá Ilich Méchnikov, Saint-Petersburg, Russia
- Noemí Fernández
- Hospital Universitario Marqués de Valdecilla, Santander, Spain
- Ali S. Omrani
- Hamad Medical Corporation, Doha, Qatar
- Rui Bergantim
- Centro Hospitalar e Universitário São João, Porto, Portugal
- Nick De Jonge
- Amsterdam UMC, Location VUmc, Amsterdam, Netherlands
- Guillemette Fouquet
- Department of Hematology, CH Sud Francilien, Corbeil Essonnes, France
- Milan Navrátil
- University Hospital Ostrava, Ostrava, Czech Republic
- Ghaith Abu-Zeinah
- Weill Cornell Medicine, New York, United States
- Michail Samarkos
- Laikon Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
- Johan Maertens
- KU Leuven, Leuven, Belgium
- Cristina De Ramón
- Hospital Universitario de Salamanca, Salamanca, Spain
- Anna Guidetti
- University of Milan and Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy
- Ferenc Magyari
- Division of Hematology, Department of Internal Medicine, University of Debrecen, Debrecen, Hungary
- Tomás José González-López
- Department of Hematology, Hospital Universitario de Burgos, Burgos, Spain
- Tobias Lahmer
- Medizinische Klinik II, Klinikum Rechts der Isar, TU München, Munich, Germany
- Olimpia Finizio
- UOC Hematology, AORN Cardarelli, Naples, Italy
- Natasha Ali
- Aga Khan University, Karachi, Pakistan
- László Imre Pinczés
- Division of Hematology, Department of Internal Medicine, University of Debrecen, Debrecen, Hungary
- Esperanza Lavilla-Rubira
- Hospital Universitario Lucus Augusti, Lugo, Spain
- Alessandra Romano
- AOU Policlinico Rodolico San Marco, Catania, Italy
- Maria Merelli
- Azienda Sanitaria Universitaria del Friuli Centrale, Udine, Italy
- Mario Delia
- Hematology and Stem Cell Transplantation Unit, AOUC Policlinico, Bari, Italy
- Maria Calbacho
- Hospital Universitario 12 de Octubre, Madrid, Spain
- Joseph Meletiadis
- Clinical Microbiology Laboratory, Medical School, “Attikon” University General Hospital, National and Kapodistrian University of Athens, Athens, Greece
- Darko Antić
- University Clinical Center of Serbia, Belgrade, Serbia
- José-Ángel Hernández-Rivas
- Hospital Universitario Infanta Leonor, Madrid, Spain
- Joyce Marques de Almeida
- Istituto Oncologico della Svizzera Italiana, Bellinzona, Switzerland
- Murtadha Al-Khabori
- Sultan Qaboos University Hospital, Muscat, Oman
- Martin Hoenigl
- Division of Infectious Diseases, ECMM Excellence Center for Clinical Mycology, Department of Internal Medicine, Medical University of Graz, Austria; BioTechMed, Graz, Austria
- Maria Chiara Tisi
- San Bortolo Hospital, Vicenza, Italy
- Nina Khanna
- University Hospital of Basel, Basel, Switzerland
- Aleksandra Barać
- University Clinical Center of Serbia, Belgrade, Serbia
- Noha Eisa
- Aseer Central Hospital, Abha, Saudi Arabia; Oncology Center Mansoura University, Mansoura, Egypt
- Roberta Di Blasi
- Hopital Saint Louis, Paris, France
- Raphaël Liévin
- Hopital Saint Louis, Paris, France
- Carolina Miranda-Castillo
- Hospital Rey Juan Carlos, Móstoles, Spain
- Nathan C. Bahr
- University of Kansas Medical Center, Kansas City, United States
- Sylvain Lamure
- Department of Clinical Hematology, Montpellier University Hospital, IGMM UMR5535 CNRS, University of Montpellier, Montpellier, France
- Mario Virgilio Papa
- Azienda Ospedaliera Sant'Anna e San Sebastiano, Caserta, Italy
- Ayel Yahya
- Aseer Central Hospital, Abha, Saudi Arabia
- Avinash Aujayeb
- Northumbria Healthcare, Newcastle, United Kingdom
- Jan Novák
- University Hospital of Královské Vinohrady, Prague, Czech Republic
- Nurettin Erben
- Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine Eskisehir Osmangazi University, Eskisehir, Turkey
- María Fernández-Galán
- Hospital Universitario Virgen del Puerto, Plasencia, Spain
- José-María Ribera-Santa Susana
- Clinical Hematology Department, ICO-Hospital Germans Trias i Pujol, Josep Carreras Research Institute, Badalona, Spain
- Ikhwan Rinaldi
- Cipto Mangunkusumo General Hospital, Jakarta, Indonesia
- Rita Fazzi
- Hematology and Stem Cell Transplant Unit, Osperadiela University Pisana Company, Pisa, Italy
- Monica Piedimonte
- “Sapienza” University of Rome, Rome, Italy
- Rémy Duléry
- Service d'Hématologie Clinique et de Thérapie Cellulaire, Hôpital Saint Antoine, Assistance Publique-Hôpitaux de Paris, Sorbonne Université, Inserm UMRs 938, Paris, France
- Yung Gonzaga
- Instituto Nacional do Cancer, Rio de Janeiro, Brazil
- Andrés Soto-Silva
- Faculty of Medicine, University of Chile. Infectious Diseases Unity, Salvador Hospital of Santiago, Santiago de Chile, Chile
- Giuseppe Sapienza
- Azienda Ospedaliera “Ospedali Riuniti Villa Sofia-Cervello”, Palermo, Italy
- Alexandra Serris
- Necker-Enfants Malades Hospitals, Paris, France
- Ľuboš Drgoňa
- Comenius University and National Cancer Institute, Bratislava, Slovakia
- Ana Groh
- Universitätsklinikum Frankfurt am Main, Frankfurt am Main, Germany
- Laura Serrano
- Hospital Universitario de Cabueñes, Gijón, Spain
- Eleni Gavriilaki
- General Hospital of Thessaloniki “George Papanikolaou”, Thessaloniki, Greece
- Athanasios Tragiannidis
- General Hospital of Thessaloniki “George Papanikolaou”, Thessaloniki, Greece
- Juergen Prattes
- Medical University of Graz, Graz, Austria
- Nicola Coppola
- Department of Mental Health and Public Medicine, University of Campania, Naples, Italy
- Vladimir Otašević
- University Clinical Center of Serbia, Belgrade, Serbia
- Miloš Mladenović
- COVID Hospital “Batajnica”, Belgrade, Serbia
- Mirjana Mitrović
- University Clinical Center of Serbia, Belgrade, Serbia
- Bojana Mišković
- Center for Radiology, University Clinical Center of Serbia, Belgrade, Serbia
- Pavel Jindra
- University Hospital Pilsen, Pilsen, Czech Republic
- Sofia Zompi
- Stem Cell Transplant Center, AOU Citta’ della Salute e della Scienza, Turin, Italy
- Maria Vittoria Sacchi
- Hematology and Transplant Unit, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy
- Carolin Krekeler
- Department of Medicine A for Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany
- Maria Stefania Infante
- Hospital Universitario Infanta Leonor, Madrid, Spain
- Daniel García-Bordallo
- Hospital Universitario Lucus Augusti, Lugo, Spain
- Gökçe Melis Çolak
- Department of Infectious Diseases and Clinical Microbiology, School of Medicine, Marmara University, Istanbul, Turkey
- Jiří Mayer
- Masaryk University and University Hospital Brno - Department of Internal Medicine, Hematology and Oncology, Brno, Czech Republic
- Marietta Nygaard
- Zealand University Hospital, Roskilde, Denmark
- Michaela Hanáková
- Institute of Hematology and Blood Transfusion, Prague, Czech Republic; Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
- Zdeněk Ráčil
- Institute of Hematology and Blood Transfusion, Prague, Czech Republic; Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
- Matteo Bonanni
- Hematology Unit, Fondazione Policlinico Universitario Agostino Gemelli - IRCCS, Rome, Italy; Hematology Unit, Università Cattolica del Sacro Cuore, Rome, Italy
- Philipp Koehler
- University of Cologne, Faculty of Medicine, and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany; University of Cologne, Faculty of Medicine, University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), Cologne, Germany
- Laman Rahimli
- University of Cologne, Faculty of Medicine, and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany; University of Cologne, Faculty of Medicine, University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), Cologne, Germany
- Oliver A. Cornely
- University of Cologne, Faculty of Medicine, and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany; University of Cologne, Faculty of Medicine, University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), Cologne, Germany; German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinical Trials Centre Cologne (ZKS Köln), Cologne, Germany
- Livio Pagano
- Hematology Unit, Fondazione Policlinico Universitario Agostino Gemelli - IRCCS, Rome, Italy; Hematology Unit, Università Cattolica del Sacro Cuore, Rome, Italy; Corresponding author. Fondazione Policlinico Universitario A. Gemelli – IRCCS – Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, Rome 00168, Italy.
- Francisco Javier Martín-Vallejo
- Przemyslaw Zdziarski
- Hossein Zarrinfer
- Jana Wittig
- Sein Win
- Vivien Wai-Man
- Benjamín Víšek
- Donald C. Vinh
- Maria Vehreschild
- Gina Varricchio
- Panagiotis Tsirigotis
- Ana Torres-Tienza
- Alina Daniela Tanase
- Agostino Tafuri
- Maria Stamouli
- Jiří Sramek
- Carole Soussain
- Ayten Shirinova
- Jörg Schubert
- Enrico Schalk
- Mohammad Reza Salehi
- Modar Saleh
- Giorgio Rosati
- Elisa Roldán
- Florian Reizine
- Mayara Rêgo
- Isabel Regalado-Artamendi
- Marina Popova
- Fernando Pinto
- Laure Philippe
- Hans Martin Orth
- Hans-Beier Ommen
- Aleš Obr
- Lucía Núñez-Martín-Buitrago
- Nicolas Noël
- Julia Neuhann
- Gianpaolo Nadali
- Julia A. Nacov
- Ana M. Munhoz Alburquerque
- Maria Enza Mitra
- Malgorzata Mikulska
- Sibylle Mellinghoff
- Ben Mechtel
- Juan-Alberto Martín-González
- Sandra Malak
- Jorge Loureiro-Amigo
- Lisset Lorenzo De La Peña
- Giulia Liberti
- Marianne Landau
- Ira Lacej
- Martin Kolditz
- Chi Shan Kho
- Reham Abdelaziz Khedr
- Meinolf Karthaus
- Linda Katharina Karlsson
- María-Josefa Jiménez-Lorenzo
- Macarena Izuzquiza
- Baerbel Hoell-Neugebauer
- Raoul Herbrecht
- Christopher H. Heath
- Fabio Guolo
- Jan Grothe
- Antonio Giordano
- Sergey Gerasymchuk
- Ramón García-Sanz
- Nicole García-Poutón
- Vaneuza Araújo Moreira Funke
- Monica Fung
- Charlotte Flasshove
- Luana Fianchi
- Jenna Essame
- Matthias Egger
- Bernard Drenou
- Giulia Dragonetti
- Maximilian Desole
- Roberta Della Pepa
- Bénédicte Deau Fischer
- Elizabeth De Kort
- Erik De Cabo
- François Danion
- Etienne Daguindau
- Tania Cushion
- Louise Cremer
- Marianna Criscuolo
- Gregorio Cordini
- Antonella Cingolani
- Fabio Ciceri
- Fazle Rabbi Chowdhury
- Ekaterina Chelysheva
- Adrien Chauchet
- Louis Yi Ann Chai
- M. Mansour Ceesay
- Elena Busch
- Mathias Brehon
- Davimar M.M. Borducchi
- Stephen Booth
- Serge Bologna
- Caroline Berg Venemyr
- Rebeca Bailén-Almorox
- Anastasia Antoniadou
- Amalia N. Anastasopoulou
- Fevzi Altuntaş
- Journal volume & issue
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Vol. 71
p. 102553
Abstract
Summary: Background: The COVID-19 pandemic heightened risks for individuals with hematological malignancies due to compromised immune systems, leading to more severe outcomes and increased mortality. While interventions like vaccines, targeted antivirals, and monoclonal antibodies have been effective for the general population, their benefits for these patients may not be as pronounced. Methods: The EPICOVIDEHA registry (National Clinical Trials Identifier, NCT04733729) gathers COVID-19 data from hematological malignancy patients since the pandemic's start worldwide. It spans various global locations, allowing comprehensive analysis over the first three years (2020–2022). Findings: The EPICOVIDEHA registry collected data from January 2020 to December 2022, involving 8767 COVID-19 cases in hematological malignancy patients from 152 centers across 41 countries, with 42% being female. Over this period, there was a significant reduction in critical infections and an overall decrease in mortality from 29% to 4%. However, hospitalization, particularly in the ICU, remained associated with higher mortality rates. Factors contributing to increased mortality included age, multiple comorbidities, active malignancy at COVID-19 onset, pulmonary symptoms, and hospitalization. On the positive side, vaccination with one to two doses or three or more doses, as well as encountering COVID-19 in 2022, were associated with improved survival. Interpretation: Patients with hematological malignancies still face elevated risks, despite reductions in critical infections and overall mortality rates over time. Hospitalization, especially in ICUs, remains a significant concern. The study underscores the importance of vaccination and the timing of COVID-19 exposure in 2022 for enhanced survival in this patient group. Ongoing monitoring and targeted interventions are essential to support this vulnerable population, emphasizing the critical role of timely diagnosis and prompt treatment in preventing severe COVID-19 cases. Funding: Not applicable.