Frontiers in Immunology (Sep 2022)
CARD9 deficiency predisposing chromoblastomycosis: A case report and comparative transcriptome study
- Chen Huang,
- Chen Huang,
- Chen Huang,
- Chen Huang,
- Weiwei Deng,
- Weiwei Deng,
- Weiwei Deng,
- Weiwei Deng,
- Yi Zhang,
- Yi Zhang,
- Yi Zhang,
- Yi Zhang,
- Kai Zhang,
- Kai Zhang,
- Kai Zhang,
- Kai Zhang,
- Yubo Ma,
- Yubo Ma,
- Yubo Ma,
- Yubo Ma,
- Yinggai Song,
- Yinggai Song,
- Yinggai Song,
- Yinggai Song,
- Zhe Wan,
- Zhe Wan,
- Zhe Wan,
- Zhe Wan,
- Xiaowen Wang,
- Xiaowen Wang,
- Xiaowen Wang,
- Xiaowen Wang,
- Ruoyu Li,
- Ruoyu Li,
- Ruoyu Li,
- Ruoyu Li
Affiliations
- Chen Huang
- Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China
- Chen Huang
- Research Center for Medical Mycology, Peking University, Beijing, China
- Chen Huang
- Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, China
- Chen Huang
- National Clinical Research Center for Skin and Immune Diseases, Beijing, China
- Weiwei Deng
- Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China
- Weiwei Deng
- Research Center for Medical Mycology, Peking University, Beijing, China
- Weiwei Deng
- Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, China
- Weiwei Deng
- National Clinical Research Center for Skin and Immune Diseases, Beijing, China
- Yi Zhang
- Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China
- Yi Zhang
- Research Center for Medical Mycology, Peking University, Beijing, China
- Yi Zhang
- Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, China
- Yi Zhang
- National Clinical Research Center for Skin and Immune Diseases, Beijing, China
- Kai Zhang
- Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China
- Kai Zhang
- Research Center for Medical Mycology, Peking University, Beijing, China
- Kai Zhang
- Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, China
- Kai Zhang
- National Clinical Research Center for Skin and Immune Diseases, Beijing, China
- Yubo Ma
- Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China
- Yubo Ma
- Research Center for Medical Mycology, Peking University, Beijing, China
- Yubo Ma
- Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, China
- Yubo Ma
- National Clinical Research Center for Skin and Immune Diseases, Beijing, China
- Yinggai Song
- Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China
- Yinggai Song
- Research Center for Medical Mycology, Peking University, Beijing, China
- Yinggai Song
- Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, China
- Yinggai Song
- National Clinical Research Center for Skin and Immune Diseases, Beijing, China
- Zhe Wan
- Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China
- Zhe Wan
- Research Center for Medical Mycology, Peking University, Beijing, China
- Zhe Wan
- Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, China
- Zhe Wan
- National Clinical Research Center for Skin and Immune Diseases, Beijing, China
- Xiaowen Wang
- Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China
- Xiaowen Wang
- Research Center for Medical Mycology, Peking University, Beijing, China
- Xiaowen Wang
- Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, China
- Xiaowen Wang
- National Clinical Research Center for Skin and Immune Diseases, Beijing, China
- Ruoyu Li
- Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China
- Ruoyu Li
- Research Center for Medical Mycology, Peking University, Beijing, China
- Ruoyu Li
- Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, China
- Ruoyu Li
- National Clinical Research Center for Skin and Immune Diseases, Beijing, China
- DOI
- https://doi.org/10.3389/fimmu.2022.984093
- Journal volume & issue
-
Vol. 13
Abstract
CARD9 mutations are known to predispose patients to phaeohyphomycosis caused by different dematiaceous fungal species. In this study, we report for the first time a patient of chromoblastomycosis caused by Phialophora expanda, who harbored CARD9 mutation. Through a series of in vivo and in vitro studies, especially a comparative transcriptome study, we compared this case with our former patient suffering from phaeohyphomycosis caused by Phialophora americana. We showed that P. expanda is prone to forming sclerotic bodies both in vitro and in Card9 knockout mice, and has a stronger immunogenicity than P. americana. These data preliminary demonstrated that besides host defense, fungal specificity also contributed to the clinical phenotype in CARD9 deficient patients with dematiaceous fungal infections.
Keywords
