Successful treatment of Cryptococcus neoformans immune reconstitution inflammatory syndrome in an immunocompetent host using thalidomide

Lucy K. Somerville; Andrew P. Henderson; Sharon C.A. Chen; Jen Kok

doi:10.1016/j.mmcr.2014.12.003

Medical Mycology Case Reports (Mar 2015)

Successful treatment of Cryptococcus neoformans immune reconstitution inflammatory syndrome in an immunocompetent host using thalidomide

Lucy K. Somerville,
Andrew P. Henderson,
Sharon C.A. Chen,
Jen Kok

Affiliations

Lucy K. Somerville: Centre for Infectious Diseases and Microbiology Laboratory Services, Level 3 Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales 2145, Australia
Andrew P. Henderson: Department of Neurology, Westmead Hospital, Westmead, New South Wales, Australia
Sharon C.A. Chen: Centre for Infectious Diseases and Microbiology Laboratory Services, Level 3 Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales 2145, Australia
Jen Kok: Centre for Infectious Diseases and Microbiology Laboratory Services, Level 3 Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales 2145, Australia

DOI: https://doi.org/10.1016/j.mmcr.2014.12.003
Journal volume & issue: Vol. 7, no. C
pp. 12 – 14

Abstract

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Immune reconstitution inflammatory syndrome (IRIS) can complicate antifungal treatment of cryptococcosis. There are limited data on managing cryptococcal-associated IRIS. We describe an immunocompetent patient who developed IRIS complicating Cryptococcus neoformans meningitis, successfully treated with thalidomide following failure of corticosteroid therapy. Data on thalidomide use in cryptococcal IRIS are awaited.

Published in Medical Mycology Case Reports

ISSN: 2211-7539 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General); Science: Biology (General)
Website: https://www.journals.elsevier.com/medical-mycology-case-reports/

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