Nature Communications (Apr 2018)
Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome
- Gabriel Balmus,
- Delphine Larrieu,
- Ana C. Barros,
- Casey Collins,
- Monica Abrudan,
- Mukerrem Demir,
- Nicola J. Geisler,
- Christopher J. Lelliott,
- Jacqueline K. White,
- Natasha A. Karp,
- James Atkinson,
- Andrea Kirton,
- Matt Jacobsen,
- Dean Clift,
- Raphael Rodriguez,
- Sanger Mouse Genetics Project,
- David J. Adams,
- Stephen P. Jackson
Affiliations
- Gabriel Balmus
- The Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge
- Delphine Larrieu
- The Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge
- Ana C. Barros
- The Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge
- Casey Collins
- The Wellcome Trust Sanger Institute, Hinxton
- Monica Abrudan
- The Wellcome Trust Sanger Institute, Hinxton
- Mukerrem Demir
- The Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge
- Nicola J. Geisler
- The Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge
- Christopher J. Lelliott
- The Wellcome Trust Sanger Institute, Hinxton
- Jacqueline K. White
- The Wellcome Trust Sanger Institute, Hinxton
- Natasha A. Karp
- The Wellcome Trust Sanger Institute, Hinxton
- James Atkinson
- Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca
- Andrea Kirton
- The Wellcome Trust Sanger Institute, Hinxton
- Matt Jacobsen
- Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca
- Dean Clift
- Laboratory of Molecular Biology
- Raphael Rodriguez
- Institut Curie, PSL Research University
- Sanger Mouse Genetics Project
- David J. Adams
- The Wellcome Trust Sanger Institute, Hinxton
- Stephen P. Jackson
- The Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge
- DOI
- https://doi.org/10.1038/s41467-018-03770-3
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Hutchinson-Gilford Progeria Syndrome is characterized by premature aging with cardiovascular disease being the main cause of death. Here the authors show that inhibition of the NAT10 enzyme enhances cardiac function and fitness, and reduces age-related phenotypes in a mouse model of premature aging.
