Pravastatin But Not Simvastatin Improves Survival and Neurofunctional Outcome After Cardiac Arrest and Cardiopulmonary Resuscitation

Stefan Bergt, MD; Andrea Grub, MD; Steffen Wagner, MD; Hauke Engelke, MD; Gabriele Nöldge-Schomburg, MD; Brigitte Vollmar, MD; Jan P. Roesner, MD; Nana-Maria Wagner, MD

JACC: Basic to Translational Science (Apr 2017)

Pravastatin But Not Simvastatin Improves Survival and Neurofunctional Outcome After Cardiac Arrest and Cardiopulmonary Resuscitation

Stefan Bergt, MD,
Andrea Grub, MD,
Steffen Wagner, MD,
Hauke Engelke, MD,
Gabriele Nöldge-Schomburg, MD,
Brigitte Vollmar, MD,
Jan P. Roesner, MD,
Nana-Maria Wagner, MD

Affiliations

Stefan Bergt, MD: Clinic for Anesthesiology and Critical Care Medicine, University Hospital Rostock, Rostock, Germany
Andrea Grub, MD: Clinic for Anesthesiology and Critical Care Medicine, University Hospital Rostock, Rostock, Germany
Steffen Wagner, MD: Clinic for Anesthesiology and Critical Care Medicine, University Hospital Rostock, Rostock, Germany
Hauke Engelke, MD: Clinic for Anesthesiology and Critical Care Medicine, University Hospital Rostock, Rostock, Germany
Gabriele Nöldge-Schomburg, MD: Institute for Experimental Surgery, University Hospital Rostock, Rostock, Germany
Brigitte Vollmar, MD: Institute for Experimental Surgery, University Hospital Rostock, Rostock, Germany
Jan P. Roesner, MD: Clinic for Anesthesiology and Critical Care Medicine, University Hospital Rostock, Rostock, Germany
Nana-Maria Wagner, MD: Clinic for Anesthesiology and Critical Care Medicine, University Hospital Rostock, Rostock, Germany; Address for correspondence: Dr. med. Nana-Maria Wagner, Department of Anesthesiology and Intensive Care Medicine, University Hospital Münster, Albert-Schweitzer-Campus 1, 48149 Münster, Germany.

Journal volume & issue: Vol. 2, no. 2
pp. 149 – 159

Abstract

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Summary: Cardiac arrest (CA) followed by cardiopulmonary resuscitation (CPR) is associated with high mortality and poor neurological outcome. We compared the effects of pravastatin and simvastatin on survival and neurofunction in a murine model of CA/CPR. Pravastatin, a hydrophilic statin, increased survival and neurofunction during a 28-day follow-up period. This therapy was associated with improved pulmonary function, reduced pulmonary edema, and increased endothelial cell function in vitro. In contrast, lipophilic simvastatin did not modulate survival but increased pulmonary edema and impaired endothelial cell function. Although pravastatin may display a therapeutic option for post-CA syndrome, the application of simvastatin may require re-evaluation. Key Words: cardiac arrest, endothelial cell function, ischemia and reperfusion injury, pravastatin, resuscitation, simvastatin

Published in JACC: Basic to Translational Science

ISSN: 2452-302X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-basic-to-translational-science/

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