Frontiers in Pharmacology (Oct 2022)
Single-cell RNA sequencing in atherosclerosis: Mechanism and precision medicine
- Qiaoyu Li,
- Qiaoyu Li,
- Qiaoyu Li,
- Qiaoyu Li,
- Mengchen Wang,
- Mengchen Wang,
- Mengchen Wang,
- Mengchen Wang,
- Shuxia Zhang,
- Shuxia Zhang,
- Shuxia Zhang,
- Shuxia Zhang,
- Meiqi Jin,
- Meiqi Jin,
- Meiqi Jin,
- Meiqi Jin,
- Rongchang Chen,
- Rongchang Chen,
- Rongchang Chen,
- Rongchang Chen,
- Yun Luo,
- Yun Luo,
- Yun Luo,
- Yun Luo,
- Xiaobo Sun,
- Xiaobo Sun,
- Xiaobo Sun,
- Xiaobo Sun
Affiliations
- Qiaoyu Li
- Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, China
- Qiaoyu Li
- Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, China
- Qiaoyu Li
- Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, China
- Qiaoyu Li
- NMPA Key Laboratory for Research and Evaluation of Pharmacovigilance, Beijing, China
- Mengchen Wang
- Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, China
- Mengchen Wang
- Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, China
- Mengchen Wang
- Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, China
- Mengchen Wang
- NMPA Key Laboratory for Research and Evaluation of Pharmacovigilance, Beijing, China
- Shuxia Zhang
- Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, China
- Shuxia Zhang
- Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, China
- Shuxia Zhang
- Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, China
- Shuxia Zhang
- NMPA Key Laboratory for Research and Evaluation of Pharmacovigilance, Beijing, China
- Meiqi Jin
- Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, China
- Meiqi Jin
- Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, China
- Meiqi Jin
- Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, China
- Meiqi Jin
- NMPA Key Laboratory for Research and Evaluation of Pharmacovigilance, Beijing, China
- Rongchang Chen
- Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, China
- Rongchang Chen
- Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, China
- Rongchang Chen
- Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, China
- Rongchang Chen
- NMPA Key Laboratory for Research and Evaluation of Pharmacovigilance, Beijing, China
- Yun Luo
- Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, China
- Yun Luo
- Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, China
- Yun Luo
- Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, China
- Yun Luo
- NMPA Key Laboratory for Research and Evaluation of Pharmacovigilance, Beijing, China
- Xiaobo Sun
- Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, China
- Xiaobo Sun
- Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, China
- Xiaobo Sun
- Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, China
- Xiaobo Sun
- NMPA Key Laboratory for Research and Evaluation of Pharmacovigilance, Beijing, China
- DOI
- https://doi.org/10.3389/fphar.2022.977490
- Journal volume & issue
-
Vol. 13
Abstract
Atherosclerosis is the pathological basis of various vascular diseases, including those with high mortality, such as myocardial infarction and stroke. However, its pathogenesis is complex and has not been fully elucidated yet. Over the past few years, single-cell RNA sequencing (scRNA-seq) has been developed and widely used in many biological fields to reveal biological mechanisms at the cellular level and solve the problems of cellular heterogeneity that cannot be solved using bulk RNA sequencing. In this review, we briefly summarize the existing scRNA-seq technologies and focus on their application in atherosclerosis research to provide insights into the occurrence, development and treatment of atherosclerosis.
Keywords
