Frontiers in Pediatrics (Feb 2023)

Capsulotomy opening diameter outcomes in aphakic eyes after primary congenital cataract removal and its association

  • Qihui Zhao,
  • Qihui Zhao,
  • Qihui Zhao,
  • Pingjun Chang,
  • Pingjun Chang,
  • Yinying Zhao,
  • Yinying Zhao,
  • Dandan Wang,
  • Dandan Wang,
  • Yune Zhao,
  • Yune Zhao

DOI
https://doi.org/10.3389/fped.2023.1062144
Journal volume & issue
Vol. 11

Abstract

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AimTo observe the change of capsulotomy opening diameter (COD) in aphakic eyes after primary congenital cataract removal and investigate its influencing factors.MethodsOcular parameters, including corneal diameter (CD), axial length (AL), anterior and posterior COD (ACOD, PCOD), and age at surgery were recorded at primary congenital cataract removal and secondary intraocular lens implantation. The concentrations of 15 kinds of cytokines in aqueous humor samples collected at the primary surgery were detected. The change (Δ) of COD between two surgeries were described, and its association was analyzed.ResultsFifty eyes from 33 patients with congenital cataract who underwent primary and secondary surgery were enrolled. The changes in ACOD and PCOD were not statistically significant on the whole. ΔACOD was positively correlated with ΔCD and the concentrations of PDGF-AA, VEGF and TGF-β1. The concentration of FGF-2 and the interval between two surgeries showed negative correlations with ΔACOD and ΔPCOD.ConclusionCOD in aphakic eyes kept changing after primary surgery. The positive correlation between ΔACOD and ΔCD manifested the enlargement of ACOD was influenced by lateral eye growth. Meanwhile, ΔACOD was also associated with cytokines, indicating postoperative inflammation promoted the ACOD constriction.

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