Cancer Nanotechnology (Feb 2023)

Functional targeted therapy for glioma based on platelet membrane-coated nanogels

  • Qin Li,
  • Jinglan Shen,
  • Lingling Wu,
  • Siyun Lei,
  • Yimin Yang,
  • Weide Xu,
  • Ke Hao,
  • Yi Zhang,
  • Fei Kong,
  • Wei Yang,
  • Yaling Wang,
  • Lina Peng,
  • Kaiqiang Li,
  • Zhen Wang

DOI
https://doi.org/10.1186/s12645-023-00167-w
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 17

Abstract

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Abstract Glioma treatment remains a challenge owing to unsatisfactory targeted chemotherapy, where the blood–brain barrier (BBB) hinders the efficient uptake of therapeutics into the brain. Vasculogenic mimicry (VM) formed by invasive glioma cells negatively affects the treatment of glioma. Herein, we developed a targeted biomimetic drug delivery system comprising a doxorubicin-loaded platelet membrane-coated nanogel (DOX@PNGs). The nanogels provide great redox/pH dual responsiveness, while the platelet membrane (PLTM) promotes stability and circulation time. In vitro cellular uptake and in vivo imaging experiments demonstrated that the DOX@PNGs delivery system could penetrate the BBB, target gliomas, and destruct VM. DOX@PNGs increased drug penetration and prolonged mouse survival time during the treatment of orthotopic gliomas. These results indicate this biomimetic drug delivery system to be promising for glioma treatment and may be clinically translated in the future.

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