Nature Communications (Jun 2017)
Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis
- P. Savola,
- T. Kelkka,
- H. L. Rajala,
- A. Kuuliala,
- K. Kuuliala,
- S. Eldfors,
- P. Ellonen,
- S. Lagström,
- M. Lepistö,
- T. Hannunen,
- E. I. Andersson,
- R. K. Khajuria,
- T. Jaatinen,
- R. Koivuniemi,
- H. Repo,
- J. Saarela,
- K. Porkka,
- M. Leirisalo-Repo,
- S. Mustjoki
Affiliations
- P. Savola
- University of Helsinki and Department of Hematology, Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Centre
- T. Kelkka
- University of Helsinki and Department of Hematology, Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Centre
- H. L. Rajala
- University of Helsinki and Department of Hematology, Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Centre
- A. Kuuliala
- Bacteriology and Immunology, Medicum, University of Helsinki
- K. Kuuliala
- Bacteriology and Immunology, Medicum, University of Helsinki
- S. Eldfors
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- P. Ellonen
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- S. Lagström
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- M. Lepistö
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- T. Hannunen
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- E. I. Andersson
- University of Helsinki and Department of Hematology, Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Centre
- R. K. Khajuria
- University of Helsinki and Department of Hematology, Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Centre
- T. Jaatinen
- Histocompatibility Testing Laboratory, Finnish Red Cross Blood Service
- R. Koivuniemi
- Department of Rheumatology, University of Helsinki and Helsinki University Hospital
- H. Repo
- Bacteriology and Immunology, Medicum, University of Helsinki
- J. Saarela
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- K. Porkka
- University of Helsinki and Department of Hematology, Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Centre
- M. Leirisalo-Repo
- Department of Rheumatology, University of Helsinki and Helsinki University Hospital
- S. Mustjoki
- University of Helsinki and Department of Hematology, Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Centre
- DOI
- https://doi.org/10.1038/ncomms15869
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
Accumulation of somatic mutations in lymphocytes is a feature of some cancers. Here the authors show that patients with recent onset of rheumatoid arthritis also accumulate mutations in their expanded CD8+ effector memory T cell pool independent of cancer association.
