Медицинский совет (Jul 2018)

BCLC-B hepatocellular carcinoma treatment or when should the systemic therapy be started

  • V. V. Breder,
  • M. U. Pitkevich,
  • E. R. Virshke,
  • L. A. Kostyakova,
  • I. A. Dzhanyan,
  • K. K. Laktionov

DOI
https://doi.org/10.21518/2079-701X-2018-10-27-32
Journal volume & issue
Vol. 0, no. 10
pp. 27 – 32

Abstract

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Choice of the optimal therapy for BCLC-B hepatocellular carcinoma (HCC) is a significant clinical problem. Transarterial chemoembolisation (TACE) is considered to be the method of choice as this approach is reported to produce a direct effect and to have a significant survival rate. However, TACE is not always applicable and produce a survival benefit due to the clinical heterogeneity of BCLC-B HCC. The article includes different approaches for BCLC-B HCC patients, TACE prediction and refractory criteria as well as the results obtained. The necessity of timely sorafenib systemic therapy in BCLC-B and in advanced HCC after TACE is discussed. Practical application of regorafenib as the second line in HCC systemic treatment is discussed.

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