Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission

Marie Hennebelle; Zhichao Zhang; Adam H. Metherel; Alex P. Kitson; Yurika Otoki; Christine E. Richardson; Jun Yang; Kin Sing Stephen Lee; Bruce D. Hammock; Liang Zhang; Richard P. Bazinet; Ameer Y. Taha

doi:10.1038/s41598-017-02914-7

Scientific Reports (Jun 2017)

Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission

Marie Hennebelle,
Zhichao Zhang,
Adam H. Metherel,
Alex P. Kitson,
Yurika Otoki,
Christine E. Richardson,
Jun Yang,
Kin Sing Stephen Lee,
Bruce D. Hammock,
Liang Zhang,
Richard P. Bazinet,
Ameer Y. Taha

Affiliations

Marie Hennebelle: Department of Food Science and Technology, College of Agriculture and Environmental Sciences, University of California
Zhichao Zhang: Department of Food Science and Technology, College of Agriculture and Environmental Sciences, University of California
Adam H. Metherel: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto
Alex P. Kitson: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto
Yurika Otoki: Department of Food Science and Technology, College of Agriculture and Environmental Sciences, University of California
Christine E. Richardson: Department of Nutrition, College of Agriculture and Environmental Sciences, University of California
Jun Yang: Department of Entomology and Nematology, College of Agriculture and Environmental Sciences and Comprehensive Cancer Center, Medical Center, University of California
Kin Sing Stephen Lee: Department of Entomology and Nematology, College of Agriculture and Environmental Sciences and Comprehensive Cancer Center, Medical Center, University of California
Bruce D. Hammock: Department of Entomology and Nematology, College of Agriculture and Environmental Sciences and Comprehensive Cancer Center, Medical Center, University of California
Liang Zhang: Krembil Research Institute, University Health Network
Richard P. Bazinet: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto
Ameer Y. Taha: Department of Food Science and Technology, College of Agriculture and Environmental Sciences, University of California

DOI: https://doi.org/10.1038/s41598-017-02914-7
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

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Abstract Linoleic acid (LA; 18:2 n-6), the most abundant polyunsaturated fatty acid in the US diet, is a precursor to oxidized metabolites that have unknown roles in the brain. Here, we show that oxidized LA-derived metabolites accumulate in several rat brain regions during CO2-induced ischemia and that LA-derived 13-hydroxyoctadecadienoic acid, but not LA, increase somatic paired-pulse facilitation in rat hippocampus by 80%, suggesting bioactivity. This study provides new evidence that LA participates in the response to ischemia-induced brain injury through oxidized metabolites that regulate neurotransmission. Targeting this pathway may be therapeutically relevant for ischemia-related conditions such as stroke.

Published in Scientific Reports

ISSN: 2045-2322 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine; Science
Website: https://www.nature.com/srep/

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