Journal of Applied Sciences and Environmental Management (Dec 2021)

Effect of stem bark hydroalcoholic extract of cocoa (<i>T. Cacao</i>) on liver function of Wistar albino rats induced with anaemia

  • I.M. George-Opuda,
  • O.A. Adegoke,
  • O.B. Oluwatayo,
  • O.B. Odeghe,
  • J. Ndibe

DOI
https://doi.org/10.4314/jasem.v25i9.25
Journal volume & issue
Vol. 25, no. 9

Abstract

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The study investigated the effect of stem bark hydroalcoholic extract of cocoa (Theobroma cacao) on liver function of phenlyhydrazine (PHZ)-induced forty anaemic (treated) and normal albino rats divided into 8 groups of five rats each in the study. The activities of marker enzymes such as aspartate amino transferase (AST), alanine amino transferase (ALT) and alkaline phosphatase (ALP), were assayed. In addition serum total protein, total bilirubin, albumin were determined. There was a significantly (p0.005) change was recorded. In the group (anaemic rats) treated with bark extract of Theobroma cacao at the doses of 100, 200, and 500mg/kg, AST was significantly (p0.05) increase in serum total protein, total bilirubin, albumin, ALT and ALP. In the group (non anaemic rats) treated with graded doses of the extract 200mg, 500mg and 1000mg, there was a significant (p0.05) change was recorded. The study illustrate that the bark extract of Theobroma cacao possess antioxidant and membrane permeability properties. Dose of Theobroma cacao at 500mg does not have antianaemic potentials.

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