Nature Communications (Aug 2018)
Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells
- Cedric S. Tremblay,
- Jesslyn Saw,
- Sung Kai Chiu,
- Nicholas C. Wong,
- Kirill Tsyganov,
- Sarah Ghotb,
- Alison N. Graham,
- Feng Yan,
- Andrew A. Guirguis,
- Stefan E. Sonderegger,
- Nicole Lee,
- Paul Kalitsis,
- John Reynolds,
- Stephen B. Ting,
- David R. Powell,
- Stephen M. Jane,
- David J. Curtis
Affiliations
- Cedric S. Tremblay
- Australian Centre for Blood Diseases, Central Clinical School, Monash University
- Jesslyn Saw
- Australian Centre for Blood Diseases, Central Clinical School, Monash University
- Sung Kai Chiu
- Australian Centre for Blood Diseases, Central Clinical School, Monash University
- Nicholas C. Wong
- Monash Bioinformatics Platform, Monash University
- Kirill Tsyganov
- Monash Bioinformatics Platform, Monash University
- Sarah Ghotb
- Australian Centre for Blood Diseases, Central Clinical School, Monash University
- Alison N. Graham
- Murdoch Children’s Research Institute, Royal Children’s Hospital
- Feng Yan
- Australian Centre for Blood Diseases, Central Clinical School, Monash University
- Andrew A. Guirguis
- Australian Centre for Blood Diseases, Central Clinical School, Monash University
- Stefan E. Sonderegger
- Australian Centre for Blood Diseases, Central Clinical School, Monash University
- Nicole Lee
- Australian Centre for Blood Diseases, Central Clinical School, Monash University
- Paul Kalitsis
- Murdoch Children’s Research Institute, Royal Children’s Hospital
- John Reynolds
- Biostatistics Consulting Platform, Monash University
- Stephen B. Ting
- Australian Centre for Blood Diseases, Central Clinical School, Monash University
- David R. Powell
- Monash Bioinformatics Platform, Monash University
- Stephen M. Jane
- Department of Clinical Haematology, Alfred Hospital
- David J. Curtis
- Australian Centre for Blood Diseases, Central Clinical School, Monash University
- DOI
- https://doi.org/10.1038/s41467-018-06021-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Cell cycle kinetics of pre-leukemic stem cells (pre-LSCs) may be an important determinant of clonal evolution and therapeutic resistance. Here, the AUs use a transgenic T-ALL mouse model that allows non-dividing cells to be tracked and identify a subset of non-dividing pre-LSCs maintained by p21.
