Synthesizing AND gate minigene circuits based on CRISPReader for identification of bladder cancer cells

Yuchen Liu; Weiren Huang; Zhiming Cai

doi:10.1038/s41467-020-19314-7

Nature Communications (Oct 2020)

Synthesizing AND gate minigene circuits based on CRISPReader for identification of bladder cancer cells

Yuchen Liu,
Weiren Huang,
Zhiming Cai

Affiliations

Yuchen Liu: National and Local Joint Engineering Laboratory of Medical Synthetic Biology, Institute of Translational Medicine, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University Health Science Center
Weiren Huang: National and Local Joint Engineering Laboratory of Medical Synthetic Biology, Institute of Translational Medicine, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University Health Science Center
Zhiming Cai: National and Local Joint Engineering Laboratory of Medical Synthetic Biology, Institute of Translational Medicine, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University Health Science Center

DOI: https://doi.org/10.1038/s41467-020-19314-7
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 9

Abstract

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Synthetic biology logic gates can be used to distinguish healthy cells from cancer cells. Here the authors design minigene circuits that show more robust identification of cancer cells compared to traditional genetic circuits.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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