Departamento de Recursos del Mar, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional, Mérida 97310, Yucatán, Mexico
Gabriela del Carmen Canche-Naal
Laboratorio de Farmacología, Facultad de Química, Universidad Autónoma de Yucatán, Mérida 97069, Yucatán, Mexico
Rolffy Ruben Ortiz-Andrade
Laboratorio de Farmacología, Facultad de Química, Universidad Autónoma de Yucatán, Mérida 97069, Yucatán, Mexico
Gabriel Navarrete-Vázquez
Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Cuernavaca 62209, Morelos, Mexico
Emanuel Hernández-Núñez
Departamento de Posgrado e Investigación, Instituto Tecnológico Superior de Calkiní, Av. Ah Canul S/N por Carretera Federal, Calkiní 24930, Campeche, Mexico
Benzazoles, such as benzoxazoles and benzothiazoles, are compounds with important biological and pharmacological activities and important intermediaries in synthesis. This report presents the synthesis of a butanamide derived from linking 5-chloro-2-aminobenzoxazole and 2-aminobenzothiazole via 4-chlorobutanoyl chloride. The corresponding compound N-(benzothiazol-2-yl)-4-((5-chlorobenzoxazol-2-yl)aminobutanamide was obtained at a 76% global yield using accessible starting materials and a methodology in two reaction steps. Furthermore, we conducted docking studies of this compound on 3-TOP protein to explore its potential as an antidiabetic agent.
