Cancer Reports (Oct 2021)

Characteristics, management, and outcome of pediatric patients with post‐transplant lymphoproliferative disease—A 20 years' experience from Austria

  • Anna Füreder,
  • Gabriele Kropshofer,
  • Martin Benesch,
  • Michael Dworzak,
  • Sabine Greil,
  • Wolf‐Dietrich Huber,
  • Holger Hubmann,
  • Anita Lawitschka,
  • Georg Mann,
  • Ina Michel‐Behnke,
  • Thomas Müller‐Sacherer,
  • Herbert Pichler,
  • Ingrid Simonitsch‐Klupp,
  • Wolfgang Schwinger,
  • Zsolt Szepfalusi,
  • Roman Crazzolara,
  • Andishe Attarbaschi,
  • Austrian Society of Pediatric Hematology and Oncology

DOI
https://doi.org/10.1002/cnr2.1375
Journal volume & issue
Vol. 4, no. 5
pp. n/a – n/a

Abstract

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Abstract Background Management of pediatric post‐transplantation lymphoproliferative disorder (PTLD) after hematopoietic stem cell (HSCT) and solid organ transplantation (SOT) is challenging. Aim This study of 34 PTLD patients up to 19‐years old diagnosed in Austria from 2000 to 2018 aimed at assessing initial characteristics, therapy, response, and outcome as well as prognostic markers of this rare pediatric disease. Methods and results A retrospective data analysis was performed. Types of allografts were kidney (n = 12), liver (n = 7), heart (n = 5), hematopoietic stem cells (n = 4), lungs (n = 2), multi‐visceral (n = 2), small intestine (n = 1), and vessels (n = 1). Eighteen/34 were classified as monomorphic PTLD, with DLBCL accounting for 15 cases. Polymorphic disease occurred in nine, and non‐destructive lesions in six cases. One patient had a non‐classifiable PTLD. Thirteen/34 patients are surviving event‐free in first remission (non‐destructive, n = 4/6; polymorphic, n = 4/9; monomorphic, n = 6/18). Fourteen/34 patients lacked complete response to first‐line therapy, of whom seven died. Four/34 patients relapsed, of whom two died. In 3/34 patients, death occurred as a first event. The 5‐year overall and event‐free survival rates were 64% ± 9% and 35% ± 9% for the whole cohort. Among all parameters analyzed, only malignant disease as the indication for transplantation had a significantly poor influence on survival. Conclusions This study shows PTLD still to be a major cause of mortality following SOT or HSCT in children. A continued understanding of the molecular biology of the disease shall allow to decrease treatment intensity for lower risk patients and to identify patients who may benefit from newer therapy approaches to improve outcome and decrease morbidity.

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