Nature Communications (Feb 2021)
Short-lived metal-centered excited state initiates iron-methionine photodissociation in ferrous cytochrome c
- Marco E. Reinhard,
- Michael W. Mara,
- Thomas Kroll,
- Hyeongtaek Lim,
- Ryan G. Hadt,
- Roberto Alonso-Mori,
- Matthieu Chollet,
- James M. Glownia,
- Silke Nelson,
- Dimosthenis Sokaras,
- Kristjan Kunnus,
- Tim Brandt van Driel,
- Robert W. Hartsock,
- Kasper S. Kjaer,
- Clemens Weninger,
- Elisa Biasin,
- Leland B. Gee,
- Keith O. Hodgson,
- Britt Hedman,
- Uwe Bergmann,
- Edward I. Solomon,
- Kelly J. Gaffney
Affiliations
- Marco E. Reinhard
- PULSE Institute, SLAC National Accelerator Laboratory, Stanford University
- Michael W. Mara
- Department of Chemistry, Stanford University
- Thomas Kroll
- Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University
- Hyeongtaek Lim
- Department of Chemistry, Stanford University
- Ryan G. Hadt
- Department of Chemistry, Stanford University
- Roberto Alonso-Mori
- Linac Coherent Light Source, SLAC National Accelerator Laboratory, Stanford University
- Matthieu Chollet
- Linac Coherent Light Source, SLAC National Accelerator Laboratory, Stanford University
- James M. Glownia
- Linac Coherent Light Source, SLAC National Accelerator Laboratory, Stanford University
- Silke Nelson
- Linac Coherent Light Source, SLAC National Accelerator Laboratory, Stanford University
- Dimosthenis Sokaras
- Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University
- Kristjan Kunnus
- PULSE Institute, SLAC National Accelerator Laboratory, Stanford University
- Tim Brandt van Driel
- Linac Coherent Light Source, SLAC National Accelerator Laboratory, Stanford University
- Robert W. Hartsock
- PULSE Institute, SLAC National Accelerator Laboratory, Stanford University
- Kasper S. Kjaer
- PULSE Institute, SLAC National Accelerator Laboratory, Stanford University
- Clemens Weninger
- Linac Coherent Light Source, SLAC National Accelerator Laboratory, Stanford University
- Elisa Biasin
- PULSE Institute, SLAC National Accelerator Laboratory, Stanford University
- Leland B. Gee
- Department of Chemistry, Stanford University
- Keith O. Hodgson
- Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University
- Britt Hedman
- Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University
- Uwe Bergmann
- PULSE Institute, SLAC National Accelerator Laboratory, Stanford University
- Edward I. Solomon
- Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University
- Kelly J. Gaffney
- PULSE Institute, SLAC National Accelerator Laboratory, Stanford University
- DOI
- https://doi.org/10.1038/s41467-021-21423-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 8
Abstract
The dissociation mechanism of the heme axial ligand in heme proteins is not yet fully understood. The authors investigate the photodissociation dynamics of the bond between heme Fe and methionine S in ferrous cytochrome c using femtosecond time-resolved X-ray solution scattering and X-ray emission spectroscopy, simultaneously tracking electronic and nuclear structure changes.
