Nature Communications (Nov 2020)
Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity
- Joanna Cyrta,
- Anke Augspach,
- Maria Rosaria De Filippo,
- Davide Prandi,
- Phillip Thienger,
- Matteo Benelli,
- Victoria Cooley,
- Rohan Bareja,
- David Wilkes,
- Sung-Suk Chae,
- Paola Cavaliere,
- Noah Dephoure,
- Anne-Christine Uldry,
- Sophie Braga Lagache,
- Luca Roma,
- Sandra Cohen,
- Muriel Jaquet,
- Laura P. Brandt,
- Mohammed Alshalalfa,
- Loredana Puca,
- Andrea Sboner,
- Felix Feng,
- Shangqian Wang,
- Himisha Beltran,
- Tamara Lotan,
- Martin Spahn,
- Marianna Kruithof-de Julio,
- Yu Chen,
- Karla V. Ballman,
- Francesca Demichelis,
- Salvatore Piscuoglio,
- Mark A. Rubin
Affiliations
- Joanna Cyrta
- Department for BioMedical Research, University of Bern
- Anke Augspach
- Department for BioMedical Research, University of Bern
- Maria Rosaria De Filippo
- Department for BioMedical Research, Urology Research Laboratory, University of Bern
- Davide Prandi
- Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento
- Phillip Thienger
- Department for BioMedical Research, University of Bern
- Matteo Benelli
- Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento
- Victoria Cooley
- Department of Healthcare Policy and Research, Division of Biostatistics and Epidemiology, Weill Cornell Medicine
- Rohan Bareja
- The Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine
- David Wilkes
- The Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine
- Sung-Suk Chae
- Department of Laboratory Medicine and Pathology, Weill Cornell Medicine
- Paola Cavaliere
- Meyer Cancer Center, Weill Cornell Medicine
- Noah Dephoure
- Meyer Cancer Center, Weill Cornell Medicine
- Anne-Christine Uldry
- Proteomics Mass Spectrometry Core Facility, University of Bern
- Sophie Braga Lagache
- Proteomics Mass Spectrometry Core Facility, University of Bern
- Luca Roma
- Institute of Pathology and Medical Genetics, University Hospital Basel, University of Basel
- Sandra Cohen
- Department of Laboratory Medicine and Pathology, Weill Cornell Medicine
- Muriel Jaquet
- Department for BioMedical Research, University of Bern
- Laura P. Brandt
- Department for BioMedical Research, University of Bern
- Mohammed Alshalalfa
- Department of Radiation Oncology, Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco
- Loredana Puca
- Department of Medicine, Division of Medical Oncology, Weill Cornell Medicine
- Andrea Sboner
- The Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine
- Felix Feng
- Proteomics Mass Spectrometry Core Facility, University of Bern
- Shangqian Wang
- Human Oncology and Pathogenesis Program and Department of Medicine, Memorial Sloan-Kettering Cancer Center
- Himisha Beltran
- Department of Medicine, Division of Medical Oncology, Weill Cornell Medicine
- Tamara Lotan
- Department of Urology, Johns Hopkins University School of Medicine
- Martin Spahn
- Lindenhofspital Bern, Prostate Center Bern
- Marianna Kruithof-de Julio
- Department for BioMedical Research, University of Bern
- Yu Chen
- Department of Medicine, Division of Medical Oncology, Weill Cornell Medicine
- Karla V. Ballman
- Department of Healthcare Policy and Research, Division of Biostatistics and Epidemiology, Weill Cornell Medicine
- Francesca Demichelis
- The Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine
- Salvatore Piscuoglio
- Institute of Pathology and Medical Genetics, University Hospital Basel, University of Basel
- Mark A. Rubin
- Department for BioMedical Research, University of Bern
- DOI
- https://doi.org/10.1038/s41467-020-19328-1
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
The differentiation of prostate adenocarcinoma to neuroendocrine prostate cancer (CRPC-NE) is a mechanism of resistance to androgen deprivation therapy. Here the authors show that SWI/SNF chromatin-remodeling complex is deregulated in CRPC-NE and that the complex interacts with different lineage specific factors throughout prostate cancer transdifferentiation.
