Decellularized extracellular matrix materials for treatment of ischemic cardiomyopathy

Wei Liu; Xiangmei Zhang; Xiaokai Jiang; Binyao Dai; Liwen Zhang; Yang Zhu

Bioactive Materials (Mar 2024)

Decellularized extracellular matrix materials for treatment of ischemic cardiomyopathy

Wei Liu,
Xiangmei Zhang,
Xiaokai Jiang,
Binyao Dai,
Liwen Zhang,
Yang Zhu

Affiliations

Wei Liu: Center for Medical Device Evaluation, National Medical Products Administration, Beijing, 100037, China
Xiangmei Zhang: Greater Bay Area Center for Medical Device Evaluation and Inspection, National Medical Products Administration, Shenzhen, 518045, China
Xiaokai Jiang: MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering, Hangzhou, 310027, China; Zhejiang University, Hangzhou, 310027, China
Binyao Dai: MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering, Hangzhou, 310027, China; Zhejiang University, Hangzhou, 310027, China
Liwen Zhang: MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering, Hangzhou, 310027, China; Zhejiang University, Hangzhou, 310027, China; Corresponding author. MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering, Hangzhou, 310027, China.
Yang Zhu: State Key Laboratory of Transvascular Lmplantation Devices, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Zhejiang University, Hangzhou, 310027, China; Binjiang Institute of Zhejiang University, Hangzhou, 310053, China; Corresponding author. State Key Laboratory of Transvascular lmplantation Devices, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China.

Journal volume & issue: Vol. 33
pp. 460 – 482

Abstract

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Ischemic cardiomyopathy (ICM) affect millions of patients globally. Decellularized extracellular matrix materials (dECM) have components, microstructure and mechanical properties similar to healthy cardiac tissues, and can be manufactured into various forms of implantable biomaterials including injectable hydrogels or epicardial patches, which have been extensively reported to attenuate pathological left ventricular remodeling and maintain heart function. Recently, dECM medical devices for ICM treatment have been approved for clinical use or studied in clinical trials, exhibiting considerable translation potential. Cells, growth factors and other bioactive agents have been incorporated with different dECM materials to improve the therapeutic outcomes. In addition, more detailed aspects of the biological effects and mechanisms of dECM treatment are being revealed. This review summarized recent advances in dECM materials from variable sources for cardiac repair, including extraction of extracellular matrix, cell integration, smart manufacturing of injectable hydrogels and cardiac patch materials, and their therapeutic applications. Besides, this review provides an outlook on the cutting-edge development directions in the field.

Published in Bioactive Materials

ISSN: 2452-199X (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials; Science: Biology (General)
Website: https://www.keaipublishing.com/en/journals/bioactive-materials/

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