ROCK2-induced metabolic rewiring in diabetic podocytopathy

Keiichiro Matoba; Yusuke Takeda; Yosuke Nagai; Kensuke Sekiguchi; Rikako Ukichi; Hiroshi Takahashi; Daisuke Aizawa; Masahiro Ikegami; Toshiaki Tachibana; Daiji Kawanami; Yasushi Kanazawa; Tamotsu Yokota; Kazunori Utsunomiya; Rimei Nishimura

doi:10.1038/s42003-022-03300-4

Communications Biology (Apr 2022)

ROCK2-induced metabolic rewiring in diabetic podocytopathy

Keiichiro Matoba,
Yusuke Takeda,
Yosuke Nagai,
Kensuke Sekiguchi,
Rikako Ukichi,
Hiroshi Takahashi,
Daisuke Aizawa,
Masahiro Ikegami,
Toshiaki Tachibana,
Daiji Kawanami,
Yasushi Kanazawa,
Tamotsu Yokota,
Kazunori Utsunomiya,
Rimei Nishimura

Affiliations

Keiichiro Matoba: Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, The Jikei University School of Medicine
Yusuke Takeda: Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, The Jikei University School of Medicine
Yosuke Nagai: Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, The Jikei University School of Medicine
Kensuke Sekiguchi: Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, The Jikei University School of Medicine
Rikako Ukichi: Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, The Jikei University School of Medicine
Hiroshi Takahashi: Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, The Jikei University School of Medicine
Daisuke Aizawa: Department of Pathology, The Jikei University School of Medicine
Masahiro Ikegami: Department of Pathology, The Jikei University School of Medicine
Toshiaki Tachibana: Core Research Facilities for Basic Science, Research Center for Medical Science, The Jikei University School of Medicine
Daiji Kawanami: Department of Endocrinology and Diabetes Mellitus, Fukuoka University School of Medicine
Yasushi Kanazawa: Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, The Jikei University School of Medicine
Tamotsu Yokota: Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, The Jikei University School of Medicine
Kazunori Utsunomiya: Center for Preventive Medicine, The Jikei University School of Medicine
Rimei Nishimura: Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, The Jikei University School of Medicine

DOI: https://doi.org/10.1038/s42003-022-03300-4
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 9

Abstract

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ROCK2 is found to be activated in 3 diabetic models and patients with diabetes. ROCK2 deletion in podocytes protects against diabetic kidney injury, with the beneficial effect of ROCK2 inhibition observed due to rescued PPARα signaling, leading to a recovery of fatty acid metabolism.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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