Frontiers in Chemistry (May 2022)

Versatile Electrochemical Synthesis of Selenylbenzo[b]Furan Derivatives Through the Cyclization of 2-Alkynylphenols

  • Carlos V. Doerner,
  • Marcos R. Scheide,
  • Celso R. Nicoleti,
  • Daniele C. Durigon,
  • Vinícius D. Idiarte,
  • Martinho J. A. Sousa,
  • Samuel R. Mendes,
  • Sumbal Saba,
  • José S. S. Neto,
  • Guilherme M. Martins,
  • Jamal Rafique,
  • Jamal Rafique,
  • Antonio L. Braga,
  • Antonio L. Braga

DOI
https://doi.org/10.3389/fchem.2022.880099
Journal volume & issue
Vol. 10

Abstract

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We report an electrochemical oxidative intramolecular cyclization reaction between 2-alkynylphenol derivatives and different diselenides species to generate a wide variety of substituted-benzo[b]furans. Driven by the galvanostatic electrolysis assembled in an undivided cell, it provided efficient transformation into oxidant-, base-, and metal-free conditions in an open system at room temperature. With satisfactory functional group compatibility, the products were obtained in good to excellent yields.

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