Formal [3+2] Cycloaddition Reactions of Electron-Rich Aryl Epoxides with Alkenes under Lewis Acid Catalysis Affording Tetrasubstituted Tetrahydrofurans
Víctor E. Macías-Villamizar,
Luís Cuca-Suárez,
Santiago Rodríguez,
Florenci V. González
Affiliations
Víctor E. Macías-Villamizar
Departament de Química Inorgànica i Orgànica, Universitat Jaume I, 12080 Castelló, Spain
Luís Cuca-Suárez
Departamento de Química, Universidad Nacional de Colombia, Bogotá D.C. 111321, Colombia
Santiago Rodríguez
Departament de Química Inorgànica i Orgànica, Universitat Jaume I, 12080 Castelló, Spain
Florenci V. González
Departament de Química Inorgànica i Orgànica, Universitat Jaume I, 12080 Castelló, Spain
We report on the regio- and stereoselective synthesis of tetrahydrofurans by reaction between epoxides and alkenes in the presence of a Lewis acid. This is an unprecedented formal [3+2] cycloaddition reaction between an epoxide and an alkene. The chemical reaction represents a very concise synthesis of tetrahydrofurans from accessible starting compounds.
