Nature Communications (Aug 2018)

Size control in mammalian cells involves modulation of both growth rate and cell cycle duration

  • Clotilde Cadart,
  • Sylvain Monnier,
  • Jacopo Grilli,
  • Pablo J. Sáez,
  • Nishit Srivastava,
  • Rafaele Attia,
  • Emmanuel Terriac,
  • Buzz Baum,
  • Marco Cosentino-Lagomarsino,
  • Matthieu Piel

DOI
https://doi.org/10.1038/s41467-018-05393-0
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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The size of cells fluctuates but there are limited experimental methods to measure live mammalian cell sizes. Here, the authors track single cell volume (FXm) over the cell cycle and generate a mathematical framework to compare size homeostasis in datasets ranging from bacteria to mammalian cells.