Polysaccharide of Escherichia coli in the Prevention of Recurrent Urinary Tract Infection: An Evidence-Based Review

Abstract

Introduction: Recurrent urinary tract infection is frequent and it is related to morbidity, costs and growing antibiotic resistance. OM 8930 vaccine is composed by Escherichia coli polysaccharide and it is a possible prophylactic measure, but there is doubt as to its effectiveness. Material and Methods: We performed a systematic review in evidence-based medicine databases with rigorous bibliography selection. Results: We found an effective decrease of recurrences in test groups. Discussion: We recommend the administration of the vaccine as prophylaxis of recurrent cystitis. Conclusion: The vaccine has impact on the recurrent cystitis relapse rate. We suggest that more studies be carried out to evaluate the vaccine cost-benefit and its effectiveness in complicated urinary infections.

Keywords

• Adjuvantes Imunológicos/uso terapêutico
• Escherichia coli Uropatogénica
• Infecções por Escherichia coli
• Infecções Urinárias