INVESTIGATION OF CALCIUM-PHOSPHORIC EXCHANGE IN WOMEN WITH THE MENOPAUSE STATE SUFFERING FROM OSTEOARTHROSIS AND CONCOMITANT OSTEOPENIC SYNDROME
A.S. KAYSINOVA,
A.B. LEPSHOKOVA,
T.B. MENSHIKOVA,
N.K. AKHKUBEKOVA,
L.A. CHEREVASHCHENKO,
R.M. MALLAEVA
Affiliations
A.S. KAYSINOVA
Federal State Budgetary Institution «Pyatigorsk State Scientific Research Institute of Balneology» of the Federal Medical-Biological Agency, Pyatigorsk, Russia
A.B. LEPSHOKOVA
Federal State Budgetary Institution «Pyatigorsk State Scientific Research Institute of Balneology» of the Federal Medical-Biological Agency, Pyatigorsk, Russia
T.B. MENSHIKOVA
Federal State Budgetary Institution «Pyatigorsk State Scientific Research Institute of Balneology» of the Federal Medical-Biological Agency, Pyatigorsk, Russia
N.K. AKHKUBEKOVA
Federal State Budgetary Institution «Pyatigorsk State Scientific Research Institute of Balneology» of the Federal Medical-Biological Agency, Pyatigorsk, Russia
L.A. CHEREVASHCHENKO
Federal State Budgetary Institution «Pyatigorsk State Scientific Research Institute of Balneology» of the Federal Medical-Biological Agency, Pyatigorsk, Russia
R.M. MALLAEVA
Federal State Budget Educational Institution of Higher Professional Education «Dagestan State Medical University» of the Ministry of Health of the Russian Federation, Makhachkala, Russia
Objective: To study changes in calcium-phosphorus metabolism, bone metabolism and mineral bone density in osteoarthritis with the concomitant osteopenic syndrome in women with the menopause state. Methods: We examined 40 women in the state of menopause (50-60 years), patients with osteoarthrosis of the hip joints, with a duration of disease of 3-5 and more years (the main group), and 20 healthy women of the same age (control group). Results: An increase (p<0.05) of the serum level of the C-terminal telopeptide of type I collagen, a marker of bone resorption, a predominance speed of bone resorption rate over bone formation, while no significant deviations in the level of phosphatemia and calcemia were observed with a tendency to decrease activity of alkaline phosphatase and the level of osteocalcin – markers of bone formation in serum. In addition, osteopenia has been noted in various parts of the skeleton: in the spine with a predominantly trabecular type of bone structure. Conclusion: The revealed multiple correlation relationships of the main characteristic indicators of osteoarthrosis with markers of bone resorption once again testify the comorbidity of osteoarthritis with osteoporosis.
