SARS-CoV-2 IgG Levels as Predictors of XBB Variant Neutralization, Israel, 2022­ and 2023

Abstract

Although a vaccine against SARS-CoV-2 Omicron-XBB.1.5 variant is available worldwide and recent infection is protective, the lack of recorded infection data highlights the need to assess variant-specific antibody neutralization levels. We analyzed IgG levels against receptor-binding domain–specific SARS-CoV-2 ancestral strain as a correlate for high neutralizing titers against XBB variants.

Keywords

• SARS-CoV-2
• XBB variant
• IgG
• antibodies
• neutralizing antibodies
• viruses