Журнал микробиологии, эпидемиологии и иммунобиологии (Sep 2022)
COVID-19: evolution of the pandemic in Russia. Report II: dynamics of the circulation of SARS-CoV-2 genetic variants
- Vasily G. Akimkin,
- Anna Yu. Popova,
- Kamil F. Khafizov,
- Dmitry V. Dubodelov,
- Svetlana V. Ugleva,
- Tatyana A. Semenenko,
- Antonina A. Ploskireva,
- Alexander V. Gorelov,
- Natalia Yu. Pshenichnaya,
- Elena B. Yezhlova,
- Alexander N. Letyushev,
- Yulia V. Demina,
- Vladimir V. Kutyrev,
- Rinat A. Maksyutov,
- Vadim M. Govorun,
- Ivan A. Dyatlov,
- Areg A. Totolian,
- Alexandr N. Kulichenko,
- Sergey V. Balakhonov,
- Nikolay V. Rudakov,
- Olga E. Trotsenko,
- Alexey K. Noskov,
- Natalia N. Zaitseva,
- Andrey V. Toporkov,
- Dmitry A. Lioznov,
- Elena E. Andreeva,
- Olga M. Mikailova,
- Andrey G. Komarov,
- Vasily Yu. Ananyev,
- Vladimir V. Moldovanov,
- Denis Yu. Logunov,
- Vladimir A. Gushchin,
- Vladimir G. Dedkov,
- Anna S. Cherkashina,
- Stanislav N. Kuzin,
- Elena V. Tivanova,
- Larisa Yu. Kondrasheva,
- Valeria V. Saenko,
- Semyon Yu. Selezov,
- Gasan A. Gasanov,
- Nino Kh. Svanadze,
- Maxim B. Glazov,
- Aleksey A. Ostroushko,
- Konstantin O. Mironov,
- Anna S. Esman,
- Natalia A. Osina,
- Sergei A. Bodnev,
- Andrey B. Komissarov,
- Daria М. Danilenko,
- Aleksandr G. Bogun,
- Yuriy P. Skryabin,
- Kristina V. Lopatovskaya,
- Sergey V. Shtrek,
- Anna S. Volynkina,
- Anna S. Gladkikh,
- Valeria О. Kotova,
- Alexey S. Vodopyanov,
- Nadezhda A. Novikova,
- Anna S. Speranskaya,
- Andrey E. Samojlov,
- Alexey D. Neverov,
- Ivan M. Shpak
Affiliations
- Vasily G. Akimkin
- ORCiD
- Central Research Institute for Epidemiology
- Anna Yu. Popova
- ORCiD
- Federal Service for Supervision of Consumer Rights Protection and Human Welfare
- Kamil F. Khafizov
- ORCiD
- Central Research Institute for Epidemiology
- Dmitry V. Dubodelov
- ORCiD
- Central Research Institute for Epidemiology
- Svetlana V. Ugleva
- ORCiD
- Central Research Institute for Epidemiology
- Tatyana A. Semenenko
- ORCiD
- National Research Center of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya
- Antonina A. Ploskireva
- ORCiD
- Central Research Institute for Epidemiology
- Alexander V. Gorelov
- Central Research Institute for Epidemiology
- Natalia Yu. Pshenichnaya
- ORCiD
- Central Research Institute for Epidemiology
- Elena B. Yezhlova
- ORCiD
- Federal Service for Supervision of Consumer Rights Protection and Human Welfare
- Alexander N. Letyushev
- ORCiD
- Federal Service for Supervision of Consumer Rights Protection and Human Welfare
- Yulia V. Demina
- ORCiD
- Federal Service for Supervision of Consumer Rights Protection and Human Welfare
- Vladimir V. Kutyrev
- ORCiD
- Russian Research Anti-Plague Institute "Microbe"
- Rinat A. Maksyutov
- ORCiD
- State Research Centre of Virology and Biotechnology “Vector”
- Vadim M. Govorun
- ORCiD
- Institute of Disinfectology
- Ivan A. Dyatlov
- ORCiD
- State Research Center for Applied Microbiology and Biotechnology
- Areg A. Totolian
- ORCiD
- Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology
- Alexandr N. Kulichenko
- ORCiD
- Stavropol Research Anti-Plague Institute
- Sergey V. Balakhonov
- ORCiD
- Irkutsk Research Anti-Plague Institute of Siberia and the Far East
- Nikolay V. Rudakov
- ORCiD
- Omsk Research Institute of Natural Focal Infections
- Olga E. Trotsenko
- ORCiD
- Khabarovsk Research Institute of Epidemiology and Microbiology
- Alexey K. Noskov
- ORCiD
- Rostov-on-Don Researsh Anti-Plague Institute
- Natalia N. Zaitseva
- ORCiD
- Nizhny Novgorod Research Institute of Epidemiology and Microbiology
- Andrey V. Toporkov
- ORCiD
- Volgograd Research Anti-Plague Institute
- Dmitry A. Lioznov
- ORCiD
- Smorodintsev Research Institute of Influenza
- Elena E. Andreeva
- ORCiD
- Federal Service for Supervision of Consumer Rights Protection and Human Welfare for the City of Moscow
- Olga M. Mikailova
- ORCiD
- Federal Service for Supervision of Consumer Rights Protection and Human Welfare in the Moscow Region
- Andrey G. Komarov
- Diagnostic Center (Center for Laboratory Research) of the Department of Health of the City of Moscow
- Vasily Yu. Ananyev
- ORCiD
- Federal Center for Hygiene and Epidemiology
- Vladimir V. Moldovanov
- ORCiD
- Center for Hygiene and Epidemiology in the City of Moscow
- Denis Yu. Logunov
- ORCiD
- National Research Center of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya
- Vladimir A. Gushchin
- ORCiD
- National Research Center of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya
- Vladimir G. Dedkov
- ORCiD
- Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology
- Anna S. Cherkashina
- ORCiD
- Central Research Institute for Epidemiology
- Stanislav N. Kuzin
- ORCiD
- Central Research Institute for Epidemiology
- Elena V. Tivanova
- ORCiD
- Central Research Institute for Epidemiology
- Larisa Yu. Kondrasheva
- ORCiD
- Central Research Institute for Epidemiology
- Valeria V. Saenko
- ORCiD
- Central Research Institute for Epidemiology
- Semyon Yu. Selezov
- ORCiD
- Central Research Institute for Epidemiology
- Gasan A. Gasanov
- ORCiD
- Central Research Institute for Epidemiology
- Nino Kh. Svanadze
- ORCiD
- Central Research Institute for Epidemiology
- Maxim B. Glazov
- ORCiD
- Central Research Institute for Epidemiology
- Aleksey A. Ostroushko
- ORCiD
- Central Research Institute for Epidemiology
- Konstantin O. Mironov
- ORCiD
- Central Research Institute for Epidemiology
- Anna S. Esman
- ORCiD
- Central Research Institute for Epidemiology
- Natalia A. Osina
- ORCiD
- Russian Research Anti-Plague Institute "Microbe"
- Sergei A. Bodnev
- ORCiD
- State Research Centre of Virology and Biotechnology “Vector”
- Andrey B. Komissarov
- ORCiD
- Smorodintsev Research Institute of Influenza
- Daria М. Danilenko
- ORCiD
- Smorodintsev Research Institute of Influenza
- Aleksandr G. Bogun
- ORCiD
- State Research Center for Applied Microbiology and Biotechnology
- Yuriy P. Skryabin
- ORCiD
- State Research Center for Applied Microbiology and Biotechnology
- Kristina V. Lopatovskaya
- ORCiD
- Irkutsk Research Anti-Plague Institute of Siberia and the Far East
- Sergey V. Shtrek
- ORCiD
- Omsk Research Institute of Natural Focal Infections
- Anna S. Volynkina
- ORCiD
- Stavropol Research Anti-Plague Institute
- Anna S. Gladkikh
- ORCiD
- Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology
- Valeria О. Kotova
- ORCiD
- Khabarovsk Research Institute of Epidemiology and Microbiology
- Alexey S. Vodopyanov
- ORCiD
- Rostov-on-Don Researsh Anti-Plague Institute
- Nadezhda A. Novikova
- ORCiD
- Nizhny Novgorod Research Institute of Epidemiology and Microbiology
- Anna S. Speranskaya
- ORCiD
- Institute of Disinfectology
- Andrey E. Samojlov
- ORCiD
- Institute of Disinfectology
- Alexey D. Neverov
- ORCiD
- Central Research Institute for Epidemiology
- Ivan M. Shpak
- ORCiD
- Volgograd Research Anti-Plague Institute
- DOI
- https://doi.org/10.36233/0372-9311-295
- Journal volume & issue
-
Vol. 99,
no. 4
pp. 381 – 396
Abstract
Background. The ongoing pandemic of the novel coronavirus infection (COVID-19) draws attention to the significance of molecular and genetic monitoring of the SARS-CoV-2 spread among the population of the Russian Federation. The aim of the study was to analyze the dynamics of circulation of SARS-CoV-2 genetic variants in Russia. Materials and methods. The analysis of the circulation dynamics for SARS-CoV-2 genetic variants in Russia was carried out, covering the period from 28/12/2020 to 26/6/2022. The analysis included the data from Rospotrebnadzor Report No. 970 "Information about Infectious Diseases in Individuals with Suspected Novel Coronavirus Infection" and the Virus Genome Aggregator of Russia (VGARus). The presence of SARS-CoV-2 RNA was confirmed by the real-time reverse transcription polymerase chain reaction. The primer panels developed at the Central Research Institute of Epidemiology were used for amplification of genomic fragments and the subsequent sequencing. Results and discussion. Using the Russian VGARus platform developed by the Central Research Institute of Epidemiology, we received the data on mutational variability of SARS-CoV-2. By monitoring the circulation of SARS-CoV-2 genetic variants in Russia from 28/12/2020 to 26/6/2022, we found that Delta and Omicron genetic variants prevailed at different stages of the epidemic. Conclusion. The data of molecular and genetic studies are an essential component of epidemiological surveillance, being critically important for making executive decisions aimed at prevention of further spread of SARS-CoV-2 and laying the groundwork for creating new vaccines.
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